1841-19-6
1841-19-6 结构式
基本信息
中文别名
氟虫灵氟斯必灵
氟司必林
帕罗西汀 杂质C
帕罗西汀EP杂质C
氟司必林 EP标准品
英文别名
imapR 6218
Redeptin
mcn-jr-6218
Fluspirilen
FLUSPIRILENE
Fluspirilene CRS
Fluspirilene (R 6218
FLUSPIRILENE USP/EP/BP
Paroxetine EP IMpurity C
所属类别
原料药：抗精神病药物理化学性质
熔点187.5-190°
沸点668.9±55.0 °C(Predicted)
密度1.1634 (estimate)
储存条件room temp
溶解度DMSO: soluble
酸度系数(pKa)15.05±0.20(Predicted)
形态amorphous solid
颜色white to yellow
CAS 数据库1841-19-6
安全数据
警示词危险
危险性描述H410-H301
危险品运输编号3249
WGK Germany3
RTECS号XX8750000
危险等级6.1(b)
包装类别III
毒性LD50 i.m. in rats: 146 ±14 mg/kg (Janssen)
常见问题列表
生物活性
Fluspirilene是L型钙通道的非竞争性拮抗剂，IC50为0.03 μM。Fluspirileneis是一种用于精神分裂症的长效可注射抗精神病药物。靶点
IC50: 0.03 μM (L-type calcium channel)
体外研究
Fluspirilene, at concentrations which non-competitively modify dihydropyridine binding, selectively antagonizes the effects of calcium-channel activators. Fluspirilene decreases the viability and suppresses sphere-forming of glioma stem cell lines in a dose-dependent manner. Fluspirilene demonstrates the inhibition of proliferation of T98, U87 and all GSC lines at 1.25, 2.5, and 5 μM, while it inhibits the proliferation of U251 and SNB19 at 2.5 and 5 μM.
体内研究
Mice treated with fluspirilene shows a remarkable reduction of the tumor size. Fluspirilene significantly prolongs survival of the TGS04 mouse model.