2309-07-1
中文名称
阿魏酸甲酯
英文名称
FERULIC ACID METHYL ESTER
CAS
2309-07-1
分子式
C11H12O4
MDL 编号
MFCD00017208
分子量
208.21
MOL 文件
2309-07-1.mol
更新日期
2024/05/14 15:32:26
2309-07-1 结构式
基本信息
中文别名
阿魏酸甲酯4-羟基-3-甲氧基肉桂酸甲酯
英文别名
4-HYDROXY-3-METHOXYCINNAMIC ACID METHYL ESTERFERULIC ACID METHYL ESTER
METHYL 3-(4-HYDROXY-3-METHOXY)CINNAMATE
METHYL 4-HYDROXY-3-METHOXYCINNAMATE
METHYL FERULATE
METHYL TRANS-3-(4'-HYDROXY-3'-METHOXYPHENYL)-ACRYLATE
3-(4-hydroxy-3-methoxyphenyl)-2-propenoicacimethylester
4-hydroxy-3-methoxy-cinnamicacimethylester
3-(3-Methoxy-4-hydroxyphenyl)acrylic acid methyl ester
3-(4-Hydroxy-3-methoxyphenyl)propenoic acid methyl ester
3-Methoxy-4-hydroxybenzeneacrylic acid methyl ester
Maritin F
Fumalic acid methyl ester
所属类别
生物化工：提取物物理化学性质
外观性状白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于番杏科(Aizoaceae) 番杏 Tetragonia tetragonoides (Pall.)O.kuntze 叶。
熔点62-65°C
沸点163 °C(Press: 1 Torr)
密度1.204±0.06 g/cm3(Predicted)
储存条件Sealed in dry,2-8°C
溶解度Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Sparingly)
酸度系数(pKa)8.88±0.18(Predicted)
形态固体
颜色白色至灰白色
水溶解性Slightly soluble in water.
LogP2.209 (est)
常见问题列表
生物活性
Ferulic acid methyl ester (Methyl ferulate) 是从 Stemona tuberosa 中分到的阿魏酸衍生物，具有抗氧化、抗炎作用。Ferulic acid methyl ester 能够透过细胞膜和血脑屏障，清除自由基，可用于神经退行性疾病的研究。在原发性骨髓源性巨噬细胞中，Ferulic acid methyl ester 抑制 COX-2 的表达，降低 p-p38 和 p-JNK 的水平。靶点
|
p38
|
体外研究
Ferulic acid methyl ester (25 µg/mL) has no cytotoxic effects on BMDMs after treatment for 6 h, 18 h, 48 h.
Ferulic acid methyl ester (Methyl ferulate; 5, 10, 25 µg/mL) suppresses TNFα, IL6, IFNγ but not IL10, inhibits NO generation at 10 and 25 µg/mL, in primary bone marrow derived-macrophages (BMDMs).
Ferulic acid methyl ester (25 µg/mL) inhibits COX-2 expression, blocks p-p38 and p-JNK.
Cell Viability Assay
| Cell Line: | Primary bone marrow derived-macrophages (BMDMs) |
| Concentration: | 25 µg/mL |
| Incubation Time: | 6 h, 18 h, 48 h |
| Result: | Showed no cytotoxic effects on BMDMs. |
Western Blot Analysis
| Cell Line: | RAW 246.7 cells |
| Concentration: | 10 µg/mL and 25 µg/mL |
| Incubation Time: | For 1 h before stimulation with LPS |
| Result: | Significantly suppressed COX-2 expression at 25 µg/mL. |