38821-49-7
中文名称
卡比多巴
英文名称
Carbidopa Monohydrate
CAS
38821-49-7
分子式
C10H16N2O5
MDL 编号
MFCD00889211
分子量
244.24
MOL 文件
38821-49-7.mol
更新日期
2024/05/29 13:47:37
38821-49-7 结构式
基本信息
中文别名
卡比多巴单水合物卡比多巴
(S)-alpha-甲基-alpha-肼基-3,4-二羟基苯丙酸一水合物
卡比多巴
英文别名
CARBIDOPACARBIDOPA HYDRATE
CARBIDOPA MONOHYDRATE
(S)-(-)-CARBIDOPA MONOHYDRATE
(-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamicacidmonohydrat
(-)-l-alpha-hydrazino-3,4-dihydroxy-alpha-methyl-hydrocinnamicacimonohydr
alpha-hydrazino-3,4-dihydroxy-alpha-methyl-benzenepropanoicacimonohydra
lodosyn
CARBIDOPA 1-HYDRATE
CARBIDOPA 1-HYDRATE, PHARMA
CARBIDOPA,USP
CARBIDOPA(GMP CERTIFICATE)
(+)-2-(3,4-Dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate
所属类别
原料药：抗震颤麻痹药物理化学性质
储存条件Keep in dark place,Inert atmosphere,Room temperature
溶解度Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
形态neat
颜色白色至灰白色
安全数据
警示词警告
危险性描述H302-H319
WGK Germany3
RTECS号MW5300000
危险等级IRRITANT
海关编码2928002500
毒性mouse,LD50,intraperitoneal,148mg/kg (148mg/kg),SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: ATAXIABEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Toxicology and Applied Pharmacology. Vol. 29, Pg. 181, 1974.
38821-49-7(安全特性,毒性,储运)
储运特性
库房低温通风干燥毒性分级
中毒急性毒性
口服-大鼠 LD50: 4810 毫克/公斤; 口服-小鼠 LD50: 1750 毫克/公斤可燃性危险特性
热分解排出有毒氮氧化物烟雾类别
有毒物质灭火剂
水, 二氧化碳, 泡沫, 干粉常见问题列表
用途
卡比多巴为类白色绒毛状结晶；几乎无臭。与左旋多巴联合应用，用于帕金森病和帕金森综合征。生物活性
Carbidopa ((S)-(-)-Carbidopa) monohydrate 是一种外周型脱羧酶 (decarboxylase) 抑制剂，可用于帕金森病的研究。Carbidopa monohydrate 是一种选择性芳香烃受体 (AhR) 调节剂。Carbidopa monohydrate 抑制胰腺癌细胞和肿瘤生长。体外研究
Carbidopa ((S)-(-)-Carbidopa) monohydrate exhibits activities similar to that described for other AhR ligands in BχPC3 and Capan-2 cells, namely the induction of CYP1A1 and CYP1A2, which are inhibited by AhR antagonists such as CH223191.
Carbidopa, a aromatic-L-amino acid decarboxylase inhibitor, is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells. Carbidopa is lethal (IC
50
=29 μM).
体内研究
Carbidopa monohydrate also induces nuclear uptake of the AhR, and in vivo studies show that carbidopa at a dose of 1 mg/mouse significantly inhibits tumor growth in athymic nude mice bearing BχPC3 cells as xenografts.