返回ChemicalBook首页>CAS数据库列表>51-98-9

51-98-9

中文名称 炔诺酮醋酸酯
英文名称 19-Norethindrone acetate
CAS 51-98-9
EINECS 编号 200-132-0
分子式 C22H28O3
MDL 编号 MFCD04039850
分子量 340.46
MOL 文件 51-98-9.mol
更新日期 2024/05/24 14:36:22
51-98-9 结构式 51-98-9 结构式

基本信息

中文别名
醋酸炔诺酮
炔诺酮醋酸酯
17β-羟基9-去甲-17α-孕甾-4-烯-20-炔-3-酮-17-醋酸酯
17Α-乙炔基-17Β-羟基雌甾-4-烯-3-酮17-醋酸酯
17Α-乙炔基雌甾-4-烯-17Β-醇-3-酮17-醋酸酯
17Β-乙酰氧基-17Α-乙炔基雌甾-4-烯-3-酮
英文别名
17a-ethynyl-19-nortestosterone 17b-acetate
17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE 17-ACETATE
17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17BETA-ACETATE
17ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE
17-hydroxy-19-nor-17a-4-pregnen-20-yn-3-one acetate
17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE ACETATE
19-NOR-17ALPHA-ETHYNYLTESTOSTERONE ACETATE
19-NORESTHISTERONE ACETATE
19-NORETHINDRONE ACETATE
19-NORETHISTERONE 17-ACETATE
19-NORETHISTERONE ACETATE
4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE 17-ACETATE
4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE ACETATE
ACETIC ACID 17-ETHYNYL-13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPE
NORETHINDRONE ACETATE
NORETHISTERONE ACETATE
(17-alpha)-17-(Acetyloxy)-19-norpregn-4-en-20-yn-3-one
(17α)-17-(acetyloxy)-19-norpregn-4-en-20-yn-3-one
17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-on
17-acetoxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one

物理化学性质

熔点161-162°
沸点416.25°C (rough estimate)
密度1.1236 (rough estimate)
折射率-34 ° (C=1, Dioxane)
储存条件2-8°C
溶解度几乎不溶于水,易溶于二氯甲烷,溶于乙醇。
形态neat
颜色Crystals from Me2CO/hexane
水溶解性3.162mg/L(10 ºC)
Merck6697
InChIKeyIMONTRJLAWHYGT-ZCPXKWAGSA-N
NIST化学物质信息Norethindrone acetate(51-98-9)

安全数据

危险性符号(GHS)
GHS08
警示词警告
危险性描述H351
危险品标志Xn
危险类别码R40-R48
安全说明S36/37
WGK Germany3
RTECS号RC8965000
海关编码29372390
毒性dlt-mus-orl 1120 mg/kg/4W MUREAV 26,535,74

应用领域

用途一
孕激素类药,用于月经不调、子宫功能性出血、子宫内膜异位症等。

常见问题列表

简介
炔诺酮醋酸酯是一种雌性激素,可用作孕激素类药,用于月经不调、子宫功能性出血、子宫内膜异位症等。
禁忌

已知或疑有乳癌、雌激素依赖性肿瘤,有乳癌病史者,代谢性卟啉病患者。

生物活性
Norethindrone acetate 是一种雌性激素,可用于子宫内膜异位症研究。
靶点

Progesterone Receptor

体内研究

Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats.

炔诺酮醋酸酯价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30N0450醋酸炔诺酮
Norethisterone Acetate
51-98-9100MG140元
2024/04/30HY-B1710炔诺酮醋酸酯
Norethindrone acetate
51-98-9100mg300元
2024/04/30HY-B1710炔诺酮醋酸酯
Norethindrone acetate
51-98-9500mg600元
"51-98-9" 相关产品信息
68-22-4 112-07-2 631-61-8 6533-00-2 108-21-4 108-05-4 108-65-6 147245-92-9 141-78-6 111-15-9 127-09-3 1914-99-4 51-98-9