65271-80-9

中文名称米托蒽醌

英文名称 Mitoxantrone

CAS 65271-80-9

分子式 C22H28N4O6

MDL 编号 MFCD00242942

分子量 444.48

MOL 文件 65271-80-9.mol

更新日期 2024/05/15 11:01:50

65271-80-9 结构式

基本信息物理化学性质安全数据应用领域米托蒽醌价格(试剂级) 常见问题列表

基本信息

中文别名

1,4-二羟基-5,8-双[[2-[(2-羟乙基)氨基]乙基]氨基]-9,10-蒽醌
米托蒽醌
米托恩醌

英文别名

1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]-anthracene-9,10-dione
MITOXANTRONE
1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthracenedi
5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxy-anthraquinon
5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-1,4-dihydroxyanthraquinone
9,10-anthracenedione,1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)a
dihydroxyanthraquinone
mitoxanthrone
nsc279836
MitoxantroneBase
Mitoxantrone Hcl 70476-82-3 / Base
PharmasubstanceEP4
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione
NSC-27983
9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-
1,4-dihydroxy-5,8-bis(2-((2-hydroxyethyl)amino)ethylamino)-9,10-anthrace nedimitoxantrone
MITOXANTRONUM AND THE INTERMEDIATES
Mitoxantrone (base and/or unspecified salts)
MITOXANTRONUM
1,4-Dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethylamino]-9,10-anthraquinone

所属类别

原料药：抗肿瘤辅助用药

物理化学性质

外观性状蓝黑色结晶。熔点203-205℃。略溶于水，微溶于乙醇，不溶于氯仿和丙酮。无臭，易吸潮

熔点170-1740C

沸点554.47°C (rough estimate)

密度1.3049 (rough estimate)

折射率1.6500 (estimate)

储存条件Keep in dark place,Sealed in dry,2-8°C

溶解度DMSO（少量）、甲醇（少量）、水（少量）

酸度系数(pKa)pKa 5.99 (Uncertain);8.13 (Uncertain)

形态固体

颜色深蓝色到黑色

InChIInChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2

InChIKeyKKZJGLLVHKMTCM-UHFFFAOYSA-N

SMILESC1(O)=C2C(C(=O)C3=C(C2=O)C(NCCNCCO)=CC=C3NCCNCCO)=C(O)C=C1

CAS 数据库65271-80-9(CAS DataBase Reference)

(IARC)致癌物分类2B (Vol. 76) 2000

安全数据

危险性符号(GHS)

GHS08,GHS09

警示词警告

危险性描述H351-H411

防范说明P201-P202-P281-P308+P313-P405-P501

危险品标志T

危险类别码R46-R61

安全说明S53-S36/37/39-S45

WGK Germany3

RTECS号CB5748500

海关编码2922.50.2500

应用领域

用途一

蒽环类抗癌药，抗癌活性与阿霉素相似或略高，明显高于环磷酰胺、阿糖胞苷、甲氨喋呤、氟脲嘧啶、长春新碱等常用的抗癌药。临床用于乳腺癌有突出的疗效。

米托蒽醌价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	XW6527180902	米托蒽醌	65271-80-9	50MG	232元
2024/04/30	HY-13502	米托蒽醌 Mitoxantrone	65271-80-9	50mg	515元
2024/04/30	HY-13502	米托蒽醌 Mitoxantrone	65271-80-9	10mM * 1mLin DMSO	567元

常见问题列表

生物活性

Mitoxantrone是拓扑异构酶II (topoisomerase II)的抑制剂；也可抑制蛋白激酶C (PKC)， IC50值为8.5 μM。

靶点

PKC

8.5 μM (IC ₅₀ )

Topoisomerase II

体外研究

Mitoxantrone inhibits PKC in a competitive manner with respect to histone H1, and its K _i value is 6.3 μM and in a non-competitive manner with respect to phosphatidylserine and ATP. Treatment of B-CLL cells for 48 h with mitoxantrone (0.5 μg/mL) induces a decrease in cell viability. Mitoxantrone induces DNA fragmentation and the proteolytic cleavage of poly(ADP-ribose) polymerase (PARP), demonstrating that the cytotoxic effect of mitoxantrone is due to induction of apoptosis. Mitoxantrone shows cytotoxicity to human breast carcinoma cell lines MDA-MB-231 and MCF-7 with IC ₅₀ values of 18 and 196 nM, respectively.

体内研究

Mitoxantrone given IP at the optimal dose (1.6 mg/kg/day; as a free base) produces a statistically significant number of 60-day survivors (curative effect) in mice with IP implanted L1210 leukemia. In SC implanted Lewis lung carcinoma, mitoxantrone and ADM administered IV also shows effective antitumor activities and produces a 60% and a 45% ILS, respectively..