72795-01-8
72795-01-8 结构式
基本信息
CI 118551 Hydrochloride
ICI 118,551 hydrochloride, >=98%
(2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1)
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | S8114 | ICI 118,551 HYDROCHLORIDE ICI-118551 Hydrochloride | 72795-01-8 | 5mg | 1613.61元 |
| 2024/04/30 | S8114 | Zenidolol (ICI-118551) Hydrochloride | 72795-01-8 | 10mM (1mL in DMSO) | 1875.51元 |
| 2024/04/30 | S8114 | ICI 118,551 HYDROCHLORIDE ICI-118551 Hydrochloride | 72795-01-8 | 25mg | 4889.65元 |
常见问题列表
Ki: 0.7nM (β2 receptor), 49.5 nM (β1 receptor), 611 nM (β3 receptor)
ICI 118551 inhibits cAMP accumulation with IC 50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551.
ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.