77521-29-0
中文名称
(R,S)-Α-氨基-3-羟基-5-甲基-4-异恶唑丙酸
英文名称
(RS)-AMPA
CAS
77521-29-0
分子式
C7H10N2O4
分子量
186.17
MOL 文件
77521-29-0.mol
77521-29-0 结构式
基本信息
中文别名
(R,S)-Α-氨基-3-羟基-5-甲基-4-异恶唑丙酸 英文别名
AMPAC13672
AMPA HBR
(RS)-AMPA
AMPA (ZWITTERION) POTENT EXCITATORY AMI
5-Methyl-3-hydroxy-α-aminoisoxazole-4-propionic acid
2-AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPANOIC ACID
2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propanoic acid
(R,S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid
物理化学性质
熔点240 °C
密度1.386±0.06 g/cm3(Predicted)
储存条件2-8°C
储存条件2-8°C
溶解度H2O: 1.2 mg/mL
溶解度在水中的溶解度1.2 mg/mL
酸度系数(pKa)2.15±0.10(Predicted)
形态solid
颜色white
水溶解性Soluble in water (10mM, gentle warming)
稳定性吸湿性
CAS 数据库77521-29-0
常见问题列表
生物活性
(RS)-AMPA ((±)-AMPA) 是一种谷氨酸类似物，是一种有效的选择性兴奋性神经递质 L-谷氨酸 (L-glutamic acid) 激动剂。(RS)-AMPA 不会干扰海藻酸或 NMDA 受体的结合位点。体外研究
(RS)-AMPA (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors.