83701-22-8
中文名称
敏乐啶硫酸盐
英文名称
Minoxidil sulphate
CAS
83701-22-8
分子式
C9H15N5O4S
MDL 编号
MFCD06248907
分子量
289.31
MOL 文件
83701-22-8.mol
更新日期
2024/06/03 09:55:52
83701-22-8 结构式
基本信息
中文别名
6-(1-哌啶基)-2,4-嘧啶二胺-3-氧化物硫酸盐6-氨基-1,2-二氢-1-羟基-2-亚胺基-4-(1-哌啶基)嘧啶硫酸酯
米诺地尔硫酸盐
敏乐啶硫酸盐
硫酸敏乐定
硫酸米诺地尔
英文别名
6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATEMINOXIDIL SULFATE
MINOXIDIL SULPHATE
U-58838
minoxidilsulfateester
MINOXIDIL SUFATE ETHYLATED
1,6-Dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-2-pyrimidinamine
Minoxidil O-sulfate
所属类别
原料药：抗高血压病药物理化学性质
熔点175-180°C
密度1.75±0.1 g/cm3(Predicted)
RTECS号UV6260494
储存条件−20°C
溶解度可溶于丙酮（少许）、DMSO（少许）
酸度系数(pKa)-4.99±0.18(Predicted)
形态白色固体。
颜色白色至灰白色
稳定性Light Sensitive - Protect from Light, Store in Freezer
InChIInChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
InChIKeyAGMYAAIWWVATKU-UHFFFAOYSA-N
SMILESC1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
应用领域
用途1
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14碌M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.常见问题列表
用途
米诺地尔硫酸盐为白色结晶性粉末，可用作降压药，生发剂医药中间体。生物活性
Minoxidil sulfate 是一种有效的 ATP 敏感的 K+ 通道 (K+ channel) 激动剂，是米诺地尔的硫酸代谢物。Minoxidil sulfate 被认为是一种血管扩张试剂，在动物实验模型中，促进头发生长。靶点
IC50: K channel
体外研究
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Western Blot Analysis
| Cell Line: | Rat brain microvascular endothelial cells (RBMECs) |
| Concentration: | 0-100 μM |
| Incubation Time: | 15 mins, 30 mins, 1 hour, 2 hours, 4 hours |
| Result: | Induced RhoA activation and PKB phosphorylation at Ser-473. |