86-42-0
86-42-0 结构式
基本信息
氨酚喹
氨酚喹啉
7-chloro-4-(3-diethylaminomethyl-4-hydroxyanilino)quinoline
AMODIAQUIN
AMODIAQUINE
4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-creso
4-((7-Chloro-4-quinolyl)amino)-alpha-(diethylamino)-o-cresol
4-[(7-Chloro-4-quinolinyl)amino]-alpha-(diethylamino)-o-cresol
7-Chloro-4-(3-diethylaminomethyl-4-hydroxyphenylamino)quinoline
Amodiaquine, ring-closed
CAM-AQ1
CAM-AQI
Camochin
Camoquin
Camoquinal
Camoquine
Flavoquine
Miaquin
o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-(diethylamino)-
Phenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[(diethylamino)methyl]-
Quinoline, 7-chloro-4-((3-((diethylamino)methyl)-4-hydroxyphenyl)amino)-
物理化学性质
常见问题列表
EC50: ~20 μM (Nurr1-LBD (ligand binding domain))
Histamine N-methyltransferase
Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH
+
neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.
RT-PCR
| Cell Line: | Primary microglia |
| Concentration: | 10 µM, 15 µM, 20 µM |
| Incubation Time: | 4 hours |
| Result: | Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner. |
Amodiaquine (40 mg/kg; intraperitoneal injection; daily; for 3 days; male ICR mice) treatment diminishes perihematomal activation of microglia/macrophages and astrocytes. Amodiaquine also suppresses ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.
| Animal Model: | Male ICR mice (8-10 weeks of age) induced ntracerebral hemorrhage (ICH) |
| Dosage: | 40 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 3 days |
| Result: | Diminished perihematomal activation of microglia/macrophages and astrocytes. |