头孢三唑
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- CAS号:
- 65307-12-2
- 英文名:
- Cefetrizole
- 英文别名:
- Cefetrizole;(6R,7R)-8-Oxo-7-[2-thienylacetylamino]-3-[(1H-s-triazol-3-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[[2-(2-thienyl)acetyl]amino]-3-[(1H-1,2,4-triazol-5-ylthio)methyl]-, (6R,7R)-
- 中文名:
- 头孢三唑
- 中文别名:
- 头孢三唑;头孢三唑原料;化合物 T10751
- CBNumber:
- CB11178235
- 分子式:
- C16H15N5O4S3
- 分子量:
- 437.52
- MOL File:
- 65307-12-2.mol
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头孢三唑化学性质
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密度:
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1.71±0.1 g/cm3(Predicted)
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酸度系数(pKa):
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2.65±0.50(Predicted)
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头孢三唑性质、用途与生产工艺
Ceftezole 是一种 α-Glucosidase 抑制剂，其 IC50 和 Ki 值分别为 2.1 μM 和 0.578 μM。
IC50: 2.1 μM (α-Glucosidase)
Ki: 0.578 μM (α-Glucosidase)
In
in vitro
α-Glucosidase assays, Ceftezole is shown to be a reversible, non-competitive inhibitor of yeast α-glucosidase with a K
i
value of 5.78×10
-7
M when the enzyme mixture is pretreated with ceftezole.
Using an in vivo streptozotocin-induced mouse model, blood glucose levels are confirmed to be decreased by 30% 20 min after Ceftezole treatment (10 mg/kg/day). Expression levels of glycogen synthase kinase-3, peroxisome proliferator-activated receptor-γ, and uncoupling protein-3 mRNA are also slightly decreased compare to controls following Ceftezole treatment.
头孢三唑
上下游产品信息
上游原料
下游产品
65307-12-2, 头孢三唑 相关搜索:
- 化合物 T10751
- 头孢三唑原料
- 头孢三唑
- 65307-12-2
- 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[[2-(2-thienyl)acetyl]amino]-3-[(1H-1,2,4-triazol-5-ylthio)methyl]-, (6R,7R)-
- (6R,7R)-8-Oxo-7-[2-thienylacetylamino]-3-[(1H-s-triazol-3-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
- Cefetrizole