嘧苯十六铵
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- CAS号:
- 553-08-2
- 英文名:
- HEXADECYL[2-([P-METHOXYBENZYL]-2-PYRIMIDINYLAMINO)ETHYL]DIMETHYL-AMMONIUM BROMIDE
- 英文别名:
- NC-1264;NSC-5648;Tonzonium;tonzonium bromide;THONZONIUM BROMIDE;1-Hexadecanaminium;Thonzonium Bromide (200 mg);Thonzonium Bromide (200 mg) (DISCONTINUED);cetyl-dimethyl-[2-[p-anisyl(2-pyrimidyl)amino]ethyl]ammonium bromide;Inhibitor,inhibit,Bacterial,Thonzonium,Thonzonium Bromide,Proton Pump
- 中文名:
- 嘧苯十六铵
- 中文别名:
- 铵溴通佐;通佐溴胺;嘧苯十六铵;通佐溴铵 USP标准品
- CBNumber:
- CB1283484
- 分子式:
- C32H55BrN4O
- 分子量:
- 591.71
- MOL File:
- 553-08-2.mol
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嘧苯十六铵化学性质
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熔点:
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91-92°
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储存条件:
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Inert atmosphere,Room Temperature
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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稳定性:
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Hygroscopic
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嘧苯十六铵性质、用途与生产工艺
Thonzonium bromide，一种结构上与 Farnesol (HY-Y0248A) 相似的抗菌剂，是一种单阳离子表面活性剂，在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。Thonzonium bromide 以剂量依赖的方式抑制质子转运 (EC50=69 μM)。
Thonzonium bromide inhibits RANKL-induced OC formation, the appearance of OC-specific marker genes and bone-resorbing activity in vitro. Thonzonium bromide blocks the RANKL-induced activation of NF-κB, ERK and c-Fos as well as the induction of NFATc1 which is essential for OC formation. Thonzonium bromide disrupts F-actin ring formation resulting in disturbances in cytoskeletal structure in mature OCs during bone resorption. Thonzonium bromide exhibits protective effects in an in vivo murine model of LPS-induced calvarial osteolysis.
嘧苯十六铵
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1246 | Thonzonium bromide | | 5 mg | 312元 |
| 2024/04/30 | HY-B1246 | 嘧苯十六铵
Thonzonium bromide | 553-08-2 | 10mg | 500元 |
553-08-2, 嘧苯十六铵 相关搜索:
- TRACRIUM
- Inhibitors
- 有机化工原料
- 小分子抑制剂
- 小分子抑制剂，天然产物
- Detergents
- Cationic
- BioChemical
- C32H55N4OBr
- C32H55BrN4O
- 通佐溴铵 USP标准品
- 通佐溴胺
- 嘧苯十六铵
- 铵溴通佐
- 553-08-2
- Thonzonium Bromide (200 mg) (DISCONTINUED)
- Inhibitor,inhibit,Bacterial,Thonzonium,Thonzonium Bromide,Proton Pump
- N-(2-((4-Methoxybenzyl)(pyrimidin-2-yl)amino)ethyl)-N,N-dimethylhexadecan-1-aminium bromide
- 1-Hexadecanaminium
- Thonzonium Bromide (200 mg)
- Tonzonium
- hexadecyl-[2-[(4-methoxyphenyl)methyl-pyrimidin-2-ylamino]ethyl]-dimethylazanium bromide
- hexadecyl-[2-[(4-methoxyphenyl)methyl-pyrimidin-2-yl-amino]ethyl]-dimethyl-azanium bromide
- cetyl-dimethyl-[2-[p-anisyl(2-pyrimidyl)amino]ethyl]ammonium bromide
- NSC-5648
- NC-1264
- tonzonium bromide
- N-hexadecyl-N-(2-(N-4-methoxybenzylpyrimidin-2-ylamino)ethyl)dimethylammonium bromide
- THONZONIUM BROMIDE
- HEXADECYL[2-([P-METHOXYBENZYL]-2-PYRIMIDINYLAMINO)ETHYL]DIMETHYL-AMMONIUM BROMIDE