心菊内酯
|
|
- CAS号:
- 6754-13-8
- 英文名:
- HELENALIN
- 英文别名:
- Helelin;NSC 85236;HELENALIN;CB1492352;HELENALIN(SH);HELENALIN USP/EP/BP;Helenalin
(NSC 85236);a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione;(3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene;6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
- 中文名:
- 心菊内酯
- 中文别名:
- 海伦娜林;海伦纳林;锦鸡菊素;心菊内酯;心菊内酯/锦鸡菊素;化合物 T15467
- CBNumber:
- CB1492352
- 分子式:
- C15H18O4
- 分子量:
- 262.3
- MOL File:
- 6754-13-8.mol
|
|
|
心菊内酯化学性质
-
熔点:
-
167-168°
-
|
-
比旋光度:
-
D25 -102.8° (c = 3.64 in 95% ethanol)
-
|
-
沸点:
-
325.55°C (rough estimate)
-
|
-
密度:
-
1.0772 (rough estimate)
-
|
-
折射率:
-
1.4300 (estimate)
-
|
-
储存条件:
-
-20°
-
|
-
溶解度:
-
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
-
|
-
形态:
-
White to off-white solid.
-
|
-
酸度系数(pKa):
-
13.29±0.60(Predicted)
-
|
-
颜色:
-
White
-
|
-
稳定性:
-
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
-
|
-
LogP:
-
0.870
-
|
心菊内酯性质、用途与生产工艺
Helenalin 是一种抗炎的倍半萜内酯。Helenalin 通过直接靶向 p65 选择性抑制转录因子 NF-κB。Helenalin 具有烷基化活性,以 NF-κB 的 p65 亚基中的半胱氨酸巯基为靶点,从而抑制其 DNA 结合。
Helenalin (10 μM; 20-120 minutes) causes complete inhibition of NF-κB DNA binding after 80 minutes.
The anti-inflammatory, anti-carcinogenic phytochemical, Helenalin is a potent inhibitor of periodic Skp2 accumulation, an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression.
Western Blot Analysis
Cell Line:
|
Jurkat T cells
|
Concentration:
|
10 μM
|
Incubation Time:
|
20-120 minutes
|
Result:
|
Caused complete inhibition of NF-κB DNA binding after 80 minutes.
|
Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers to immature male ICR mice caused a rapid decrease in hepatic glutathione levels.
Animal Model:
|
Immature male ICR mice
|
Dosage:
|
25 mg/kg
|
Administration:
|
i.p.; 6 to 12 hours
|
Result:
|
Caused a rapid decrease in hepatic glutathione levels.
|
心菊内酯
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-119970 | 心菊内酯 Helenalin | 6754-13-8 | 500μg | 3595元 |
2024/04/30 | HY-119970 | 心菊内酯 Helenalin | 6754-13-8 | 1mg | 5395元 |
心菊内酯
生产厂家
全球有 66家供应商
心菊内酯国内生产厂家
6754-13-8, 心菊内酯 相关搜索:
- Miscellaneous Natural Products
- 中药对照品
- 标准品
- 分析试剂标准品
- 心菊内酯/锦鸡菊素
- 化合物 T15467
- 海伦娜林
- 海伦纳林
- 锦鸡菊素
- 心菊内酯
- 6754-13-8
- CB1492352
- HELENALIN USP/EP/BP
- (3aS,4S,4aR,7aR,8R,9aR)-4-hydroxy-4a,8-dimethyl-3-methylene-3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione
- Azuleno[6,5-b]furan-2,5-dione, 3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dimethyl-3-methylene-, (3aS,4S,4aR,7aR,8R,9aR)-
- Helelin
- NSC 85236
- Helenalin
(NSC 85236)
- [3as]-3,3aalpha,4alpha,4a,7aalpha,8,9,9aalpha-octahydro-4-hydroxy-4abeta,8alph
- azuleno(6,5-b)furan-2,5-dione,3,3a,4,4a,7a,8,9,9a-octahydro-4-hydroxy-4a,8-dim
- ambrosa-2,11(13)-dien-12-oicacid,6alpha,8beta-dihydroxy-4-oxo-,12,8-lactone
- ambrosa-2,11(13)-dien-12-oicacid,6-alpha,8-beta-dihydroxy-4-oxo-,12,8-lacton
- a-dimethyl-3-methyleneazuleno[6,5-b]-furan-2,5-dione
- 6alpha,8beta-dihydroxy-4-oxoambrosa-2,11(13)-dien-12-oicacid12,8-lactone
- HELENALIN
- HELENALIN(SH)
- (3as-(3aalpha,4alpha,4abeta,7aalpha,8alpha,9aalpha))-ethyl-3-methylene