曲奥舒凡
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- CAS号:
- 299-75-2
- 英文名:
- treosulfan
- 英文别名:
- CB-2562;Cb 40067;NSC 39069;Leo 40067;treosulfan;TREOSULPHAN;THREOSULFAN;Treosulfan D4;Dihydroxymyleran;Dihydroxybusulfan
- 中文名:
- 曲奥舒凡
- 中文别名:
- 苏消安;曲奥舒凡
- CBNumber:
- CB1926495
- 分子式:
- C6H14O8S2
- 分子量:
- 278.3
- MOL File:
- 299-75-2.mol
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曲奥舒凡化学性质
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熔点:
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76-78 °C
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沸点:
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359.3°C (rough estimate)
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密度:
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1.305 (estimate)
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折射率:
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1.5630 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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Acetone (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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12.36±0.20(Predicted)
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颜色:
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Off-White to Pale Beige
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CAS 数据库:
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299-75-2
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(IARC)致癌物分类:
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1 (Vol. 26, Sup 7, 100A) 2012
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EPA化学物质信息:
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Treosulfan (299-75-2)
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曲奥舒凡性质、用途与生产工艺
Treosulfan (NSC 39069, Treosulphan) 是一种用于常规和大剂量化疗方案的烷基化 alkylating 药剂。Treosulfan 对胰腺癌细胞系具有强大的细胞毒性。
Treosulfan is an alkylating agent. Treosulfan inhibits several cancer cell lines, such as Panc-1, Miapaca-2 and Capan-2 cells, with IC
50
s of 3.6 μg/mL, 1.8 μg/mL and 2.1 μg/mL respectively, and shows nearly 100% cytotoxicity on these cell lines at 100 μg/mL. Treosulfan (0.1-100 μg/mL) in combination with LY 188011 exhibits enhanced activity against cancer cells. However, Treosulfan (1, 2.5, 5 μg/ml) combined with 5-FU (0.1, 0.25, 0.5 μg/ml) has antagonistic effect on Panc-1 cells at intermediate and high concentrations, and on Miapaca-2 cells at all doses. Treosulfan (800 µg/mL) dramatically reduces erythrocyte forward scatter, increases the percentage of annexin-V-binding cells, [Ca
2+
]
i
, and ROS. Removal of extracellular Ca
2+
abrogates the effect of Treosulfan on annexin-V-binding.
Treosulfan (1.5 g/kg/day) induces a rapid myeloablation, depletes the splenic B and T cells in mice. Treosulfan (1.5 g/kg/day) causes olny interleukin-2 production in spleen cells for a short time and without obvious significant effect on synthesis of tumor necrosis factor-α and/or IFN-γ in mice.
曲奥舒凡
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16503 | 曲奥舒凡
Treosulfan | 299-75-2 | 5mg | 700元 |
| 2024/04/30 | HY-16503 | 曲奥舒凡
Treosulfan | 299-75-2 | 10mM * 1mLin DMSO | 770元 |
曲奥舒凡
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299-75-2, 曲奥舒凡 相关搜索:
- API
- 合成有机化合物配体
- 原料药
- C6H14O6S
- 苏消安
- 曲奥舒凡
- 299-75-2
- Treosulfan,inhibit,DNA Alkylator/Crosslinker,Inhibitor,NSC39069,NSC-39069
- Treosulfan D4
- Treosulfan (NSC-39069
- Treosulfan >=98% (HPLC)
- 1,2,3,4-Butanetetrol,1,4-diMethanesulfonate, (2S,3S)-
- L-Threitol-1,4-bis(methanesulfonate)
- L-Threitol, 1,4-bis(methanesulfonate)
- L-Threitol 1,4-dimethanesulfonate
- Dihydroxymyleran
- Dihydroxybusulfan
- Cb 40067
- 1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, [S-(R*,R*)]-
- (2S,3S)-Threitol 1,4-bismethanesulfonate
- treosulfan
- THREOSULFAN
- NSC 39069
- Leo 40067
- L-Dihydroxy-Busulfan
- CB-2562
- (2S,3S)-1-O,4-O-Di(methylsulfonyl)-L-threitol
- 1,2,3,4-butanetetrol 1,4-dimethanesulfonate
- TREOSULPHAN