N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
|
|
|
- CAS号:
- 61714-27-0
- 英文名:
- W-7 HYDROCHLORIDE
- 英文别名:
- W-7;SKL179;CS-1064;ulfonaMide;W-7 HYDROCHLORIDE;OMEGA-7 HYDROCHLORIDE;W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL;6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium
- 中文名:
- N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
- 中文别名:
- W-7盐酸盐;N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐;N-(6-氨基己基)-5-氯萘-1-磺酰胺盐酸盐;N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐;15366217190N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐;N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐
- CBNumber:
- CB2182197
- 分子式:
- C16H22Cl2N2O2S
- 分子量:
- 377.33
- MOL File:
- 61714-27-0.mol
|
|
|
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐化学性质
-
熔点:
-
220-222 °C
-
|
-
储存条件:
-
-20°C
-
|
-
溶解度:
-
methanol: 25 mg/mL, clear, colorless
-
|
-
形态:
-
Off-white crystalline solid
-
|
-
颜色:
-
White to Off-White
-
|
-
BRN:
-
6030174
-
|
-
CAS 数据库:
-
61714-27-0(CAS DataBase Reference)
-
|
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐性质、用途与生产工艺
W-7 hydrochloride 是一种选择性的钙调蛋白 (calmodulin) 拮抗剂。W-7 hydrochloride 抑制 Ca2+-钙调蛋白依赖性磷酸二酯酶 (phosphodiesterase) 和肌球蛋白轻链激酶 (myosin light chain kinase)，IC50 值分别为 28 μM 和 51 μM。W-7 hydrochloride 可诱导细胞凋亡 (apoptosis)，并具有抗癌活性。
IC50: 28 μM (Phosphodiesterase) and 51 µM (Myosin light chain kinase)
W-7 is distributed mainly in the cytoplasm, and inhibits proliferation of Chinese hamster ovary K1 (CHO-K1) cells. W-7 selectively blocks the phase of the cell cycle (G1/S boundary phase) in a manner. 25 μM W-7 arrests the growth of the cells at the G1/S boundary phase of the cell cycle.
W-7 (100 μM) exhibits a similar extent of antagonism between the contractile responses to carbachol and KCl. The increase in myosin light chain (P-LC) phosphate content in response to 1-min stimulation with 10 μM carbachol is inhibited by W-7. W-7 antagonizes the smooth muscle contraction through the inhibition of the initial increase in the P-LC phosphorylation.
Treatment with W-7 results in the dose-dependent inhibition of cell proliferation in various human multiple myeloma cell lines. W-7 induces G1 phase cell cycle arrest by downregulating cyclins and upregulating p21cip1. W-7 induces apoptosis via caspase activation; this occurred partly through the elevation of intracellular calcium levels and mitochondrial membrane potential depolarization and through inhibition of the STAT3 phosphorylation and subsequent downregulation of Mcl-1 protein.
W-7 competitively inhibits Ca
2+
/calmodulin-dependent phosphodiesterase with a K
i
value of 300 μM.
W-7 (3 mg/kg; intraperitoneal injection; on 5 consecutive days per week; female BALB/c nu mice) treatment significantly reduces tumor growth in a murine MM model.
|
Animal Model:
|
Female BALB/c nu mice (6-week-old) injected with RPMI 8226 cells
|
|
Dosage:
|
3 mg/kg
|
|
Administration:
|
Intraperitoneal injection; on 5 consecutive days per week
|
|
Result:
|
Significantly reduced tumor growth in a murine MM model.
|
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100912 | W-7 hydrochloride | | 5 mg | 480元 |
| 2024/04/30 | HY-100912 | N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
W-7 hydrochloride | 61714-27-0 | 10mM * 1mLin DMSO | 528元 |
N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
生产厂家
61714-27-0, N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐 相关搜索:
- Calcium signaling
- Protein Kinase Inhibitors and Activators
- Inhibitors
- All Inhibitors
- 药靶配体
- 合成
- BioChemical
- Antibiotics A-F
- Antibiotics A to Z
- Antibiotics
- C16H21ClN2O2SClH
- N-(6-氨基己基)-5-氯萘-1-磺酰胺盐酸盐
- N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐
- 15366217190N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
- N-(6-氨基己基)-5-氯-1-萘磺酰胺盐酸盐
- W-7盐酸盐
- N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐
- 61714-27-0
- Inhibitor,Phosphodiesterase (PDE),anti-proliferation,Calcium-modulated protein,light,chain,Apoptosis,W7 hydrochloride,W 7 hydrochloride,W 7,Ca2+,Calmodulin,W-7,inhibit,CaM,phosphodiesterase,Myosin,phosphate,antitumor
- 6-{[(5-chloronaphthalen-1-yl)sulfonyl]amino}hexan-1-aminium
- SKL179
- N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide Hydrochloride >
- 6-[(5-chloro-1-naphthalenyl)sulfonylamino]hexylammonium
- CS-1064
- W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem
- ulfonaMide
- N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride,W-7
- N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENES ULFONAMIDE
- N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide monohydrochloride
- 1-Naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-, monohydrochloride
- N-(6-Aminohexyl)-5-chloronaphthalene-1-sulphonamide hydrochloride
- W-7 HYDROCHLORIDE
- W-7
- N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULPHONAMIDE HYDROCHLORIDE
- N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HYDROCHLORIDE
- N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE HCL
- N-(6-AMINOHEXYL)-5-CHLORONAPHTHALENE-1-SULFONAMIDE HYDROCHLORIDE
- OMEGA-7 HYDROCHLORIDE