SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
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- CAS号:
- 2088525-31-7
- 英文名:
- Selective PI3Kδ Inhibitor 1
- 英文别名:
- PI3Kδ-IN-5;compound 7n;PI3Kδ-IN-7n;PI3K delta-IN-7n;SelectivePI3KδInhibitor1;Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-;Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1
- 中文名:
- SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
- 中文别名:
- PI3KΔ-IN-7N;选择性PI3KΔ抑制剂1(化合物7N);化合物SELECTIVE PI3KΔ INHIBITOR 1
- CBNumber:
- CB23379666
- 分子式:
- C23H20FN7O
- 分子量:
- 429.45
- MOL File:
- 2088525-31-7.mol
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SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble
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水溶解性:
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Water: Insoluble
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SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N性质、用途与生产工艺
Selective PI3Kδ Inhibitor 1 (compound 7n)是PI3Kδ抑制剂，对PI3Kδ的IC50为0.9 nM，其选择性比对其他I类PI3K亚型高1000倍以上。Selective PI3Kδ Inhibitor 1对PI3Kα/γ/β的IC50值分别为3670、1460、21300 nM。
| Target | Value |
PI3Kδ
(Cell-free assay)
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0.9 nM
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该化合物具有良好的药代动力学特征：良好的生物利用度和中等的体内半衰期。在大鼠中，其口服生物利用度为41%；在静脉注射后，Vss、T
1/2
和CL分别为2.8 L/kg, 3.4 h 和 12 mL/min/kg。
SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S8693 | SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
Selective PI3Kδ Inhibitor 1 (compound 7n) | 2088525-31-7 | 2mg | 1777.89元 |
| 2024/04/30 | S8693 | SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
Selective PI3Kδ Inhibitor 1 (compound 7n) | 2088525-31-7 | 5mg | 3497.44元 |
SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
生产厂家
2088525-31-7, SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N 相关搜索:
- 药靶配体
- 选择性PI3KΔ抑制剂1(化合物7N)
- 化合物SELECTIVE PI3KΔ INHIBITOR 1
- PI3KΔ-IN-7N
- 2088525-31-7
- PI3Kδ-IN-5
- Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1
- SelectivePI3KδInhibitor1
- Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-
- PI3K delta-IN-7n
- SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N
- compound 7n
- PI3Kδ-IN-7n
- SelectivePI3KδInhibitor1(compound7n)
- Selective PI3Kδ Inhibitor 1