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Selective PI3Kδ Inhibitor 1

Selective PI3Kδ Inhibitor 1 Structure
Selective PI3Kδ Inhibitor 1 structure
CAS No.
2088525-31-7
Chemical Name:
Selective PI3Kδ Inhibitor 1
Synonyms
PI3Kδ-IN-5;compound 7n;PI3Kδ-IN-7n;PI3K delta-IN-7n;SelectivePI3KδInhibitor1;Selective PI3Kδ Inhibitor 1;SelectivePI3KδInhibitor1(compound7n);SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N;Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro-;Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1
CBNumber:
CB23379666
Molecular Formula:
C23H20FN7O
Molecular Weight:
429.45
MDL Number:
MOL File:
2088525-31-7.mol
Last updated:2023-05-21 10:59:17
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Selective PI3Kδ Inhibitor 1 Properties

storage temp. Store at -20°C
solubility DMSO: 43 mg/mL (100.13 mM);Ethanol: Insoluble
Water Solubility Water: Insoluble

Selective PI3Kδ Inhibitor 1 Chemical Properties,Uses,Production

Biological Activity

Selective PI3Kδ Inhibitor 1 (compound 7n) is a PI3Kδ inhibitor with IC50 of 0.9 nM for PI3Kδ, which is more than 1000-fold selective for other class I PI3K isoforms. The IC50 values of it for PI3Kα/γ/β were 3670, 1460, and 21300 nM, respectively.

in vivo

Selective PI3Kδ Inhibitor 1 has favorable pharmacokinetic profile: good bioavailability and moderate in vivo half-life. In rats, its oral bioavailability was 41%; after intravenous injection, Vss, T 1/2 and CL were 2.8 L/kg, 3.4 h and 12 mL/min/kg, respectively .

target

TargetValue
PI3Kδ
(Cell-free assay)		 0.9 nM

Selective PI3Kδ Inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

Selective PI3Kδ Inhibitor 1 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 359 55
Zhengzhou anmousse chemical products co. LTD 0371-55289822 18737195735 483339295@qq.com China 7088 58
Absin Bioscience Inc. 021-38015121 15000105423 chenjw@absin.cn China 24734 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 sales@hasunny.com China 2380 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Shanghai Beckham Medical Technology Co., Ltd 55
Zhengzhou anmousse chemical products co. LTD 58
Absin Bioscience Inc. 58
Shanghai hongqu biomedical technology co. LTD 58
Energy Chemical 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
TargetMol Chemicals Inc. 58
Selective PI3Kδ Inhibitor 1 SelectivePI3KδInhibitor1(compound7n) PI3Kδ-IN-7n compound 7n SELECTIVE PI3KΔ INHIBITOR 1;COMPOUND 7N PI3K delta-IN-7n Benzamide, 4-[3-amino-6-[1-methyl-5-(1-phenylcyclopropyl)-1H-1,2,4-triazol-3-yl]-2-pyrazinyl]-2-fluoro- SelectivePI3KδInhibitor1 Inhibitor,inhibit,Phosphoinositide 3-kinase,PI3K,Selective PI3Kδ Inhibitor 1,Selective PI-3Kδ Inhibitor 1 PI3Kδ-IN-5 2088525-31-7