醒隆酰胺
|
|
|
- CAS号:
- 58473-74-8
- 英文名:
- TRANS-3-BROMO-N-ETHYLCINNAMAMIDE
- 英文别名:
- D03513;cinromide;Cinromide (usan/inn);LABOTEST-BB LT00453193;m-Bromo-N-ethylcinnamamide;trans-m-Bromo-N-ethylcinnamamide;TRANS-3-BROMO-N-ETHYLCINNAMAMIDE;3-(3-Bromophenyl)-N-ethylacrylamide;(E)-3-(3-Bromophenyl)-N-ethylacrylamide;(e)-3-(3-bromophenyl)-n-ethyl-2-propenamide
- 中文名:
- 醒隆酰胺
- 中文别名:
- 桂溴胺;醒隆酰胺;反-3-溴-N-乙基肉桂酰胺;反式-3-溴-N-乙基肉桂酰胺;(2E)-3-(3-溴苯基)-N-乙基-2-丙烯酰胺
- CBNumber:
- CB2477363
- 分子式:
- C11H12BrNO
- 分子量:
- 254.12
- MOL File:
- 58473-74-8.mol
|
|
|
醒隆酰胺化学性质
-
熔点:
-
89-91 °C(lit.)
-
|
-
沸点:
-
417.5±45.0 °C(Predicted)
-
|
-
密度:
-
1.369±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Sealed in dry,Room Temperature
-
|
-
溶解度:
-
Chloroform (Slightly), Methanol (Slightly)
-
|
-
形态:
-
Solid
-
|
-
酸度系数(pKa):
-
14.59±0.46(Predicted)
-
|
-
颜色:
-
Pale Beige
-
|
-
Merck:
-
13,2334
-
|
醒隆酰胺性质、用途与生产工艺
Cinromide 是一种抗惊厥药。Cinromide 抑制上皮中性氨基酸转运蛋白B0AT1 (SLC6A19)，IC50 为 0.5 μM。
Cinromide (10-100 μM) inhibits 5-HT-induced contractions in rat fundus strips by 46%. Cinromide (100 μM) inhibits monoamine oxidase prepared from both liver and brain of rats.
Cinromide shows electroshock convulsion and leptazol(pentetrazo1)-induced convulsion in mice, with ED
50
s of 60 ± 11 mg/kg, 90 ± 15 mg/kg and 80 ± 15 mg/kg, 300 ± 61 mg/kg for i.p. and oral administrion, respectively. Cinromide produces a dose-related antileptazol activity with an ED
50
value of 58 ± 11 mg/kg by i.p. administration in rats. Furthermore, Cinromide (75 mg/kg) significantly elevates the amount of leptazol needed to induce clonic seizures in the intravenously infused leptazol-threshold test in rats. Cinromide (300 mg/kg, i.p) shows no sifnificant effect on the anaesthetized open-chested dogs after 4 h treatment, neither in conscious dogs after 5-h oral treatment with 300 and 600 mg/kg of Cinromide. Cinromide (40 mg/kg, i.v.) depresses the response of the neuron to the unconditioned maxillary nerve stimulus, increasing the latency and decreasing the number of spikes, and depresses the response of the neuron to the unconditioned maxillary nerve stimulus, increasing the latency and decreasing the number of spikes. Cinromide (20, 40, 80 mg/kg, i.v.) increases the latency of the unconditioned response and segmental inhibition dose-dependently. Cinromide decreases periventricular inhibition and EEG.
醒隆酰胺
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-B1274 | 醒隆酰胺
Cinromide | 58473-74-8 | 100mg | 600元 |
| 2024/04/30 | HY-B1274 | 醒隆酰胺
Cinromide | 58473-74-8 | 10mM * 1mLin DMSO | 660元 |
醒隆酰胺
生产厂家
全球有 36家供应商
醒隆酰胺国内生产厂家
58473-74-8, 醒隆酰胺 相关搜索:
- Carbonyl Compounds
- Amides
- FOSAMAX
- Organic Building Blocks
- 小分子抑制剂
- Organic Building Blocks
- Carbonyl Compounds
- Building Blocks
- Amides
- AMINE
- BrC6H4CHCHCONHC2H5
- (2E)-3-(3-溴苯基)-N-乙基-2-丙烯酰胺
- 反-3-溴-N-乙基肉桂酰胺
- 反式-3-溴-N-乙基肉桂酰胺
- 醒隆酰胺
- 桂溴胺
- 58473-74-8
- metabolic,acid,transporter,Inhibitor,anticonvulsant,amino,neutral,inhibit,Cinromide
- (E)-3-(3-Bromophenyl)-N-ethylacrylamide
- 2-Propenamide, 3-(3-bromophenyl)-N-ethyl-, (2E)-
- 3-(3-Bromophenyl)-N-ethylacrylamide
- trans-m-Bromo-N-ethylcinnamamide
- D03513
- Cinromide (usan/inn)
- m-Bromo-N-ethylcinnamamide
- LABOTEST-BB LT00453193
- TRANS-3-BROMO-N-ETHYLCINNAMAMIDE, TECH., 90%
- cinromide
- (e)-3-(3-bromophenyl)-n-ethyl-2-propenamide
- TRANS-3-BROMO-N-ETHYLCINNAMAMIDE