WNT AGONIST 1 (CID11210285 盐酸盐)
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- CAS号:
- 853220-52-7
- 英文名:
- Wnt Agonist
- 英文别名:
- BML;-284;AMBMP;BML-284;CS-2376;Wnt Agonist;2-Amino-4-[3;Wnt agonist 1;Wnt Agonist I;BML-284 (BML 284
- 中文名:
- WNT AGONIST 1 (CID11210285 盐酸盐)
- 中文别名:
- BML 284,WNT信号激活剂;化合物WNT AGONIST 1;WNT信号激活剂(BML-284);WNT AGONIST 1 (CID11210285 盐酸盐);WNT AGONIST 1 CID11210285 盐酸盐 BML-284;2-氨基-4-[[3,4-(亚甲二氧基)苄基]氨基]-6-(3-甲氧基苯基)嘧啶;N4-(苯并[D][1,3]二氧杂环戊烯-5-基甲基)-6-(3-甲氧基苯基)嘧啶-2,4-二胺
- CBNumber:
- CB42750501
- 分子式:
- C19H18N4O3
- 分子量:
- 350.37
- MOL File:
- 853220-52-7.mol
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WNT AGONIST 1 (CID11210285 盐酸盐)化学性质
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沸点:
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623.4±65.0 °C(Predicted)
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密度:
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1.353±0.06 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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DMSO: soluble20mg/mL, clear
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酸度系数(pKa):
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6.62±0.10(Predicted)
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形态:
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Yellowish sticky solid
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颜色:
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white to beige
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WNT AGONIST 1 (CID11210285 盐酸盐)性质、用途与生产工艺
BML-284 是一种有效的细胞通透性 Wnt 信号激活剂。BML-284 诱导 TCF 依赖的转录活性，其 EC50>700 nM 。
EC50: 700 nM (TCF-dependent transcriptional activity)
BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group.
Western Blot Analysis
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Cell Line:
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Human gastric cancer cell lines MNK45 and AGS
[1]
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Concentration:
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10 µM
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Incubation Time:
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24 hours
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Result:
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Induced β-catenin expression and reserved E-cadherin and N-cadherin expression in MNK45 and AGS cells.
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BML-284 (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.
WNT AGONIST 1 (CID11210285 盐酸盐)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-19987 | WNT AGONIST 1 (CID11210285 盐酸盐)
BML-284 | 853220-52-7 | 10mM * 1mLin DMSO | 726元 |
| 2024/04/30 | HY-19987 | WNT AGONIST 1 (CID11210285 盐酸盐)
BML-284 | 853220-52-7 | 10mg | 860元 |
WNT AGONIST 1 (CID11210285 盐酸盐)
生产厂家
853220-52-7, WNT AGONIST 1 (CID11210285 盐酸盐) 相关搜索:
- 药靶配体
- 细胞生物学试剂
- BML 284,WNT信号激活剂
- 化合物WNT AGONIST 1
- WNT信号激活剂(BML-284)
- N4-(苯并[D][1,3]二氧杂环戊烯-5-基甲基)-6-(3-甲氧基苯基)嘧啶-2,4-二胺
- 2-氨基-4-[[3,4-(亚甲二氧基)苄基]氨基]-6-(3-甲氧基苯基)嘧啶
- WNT AGONIST 1 (CID11210285 盐酸盐)
- WNT AGONIST 1 CID11210285 盐酸盐 BML-284
- 853220-52-7
- N-cadherin,E-cadherin,malformed phenotype,BML 284,Wnt,inhibit,AGS,BML284,BML-284,TCF,Inhibitor,cardiac defect,MNK45
- BML-284 HCl，Wnt Agonist
- 2,4-Pyrimidinediamine, N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-
- BML
- -284
- CID 11210285 HCL（BML-284 HCl）
- BML-284;2-AMINO-4-[3;4-(METHYLENEDIOXY)BENZYLAMINO]-6-(3-METHOXYPHENYL)PYRIMIDINE
- 4-(methylenedioxy)benzylamino]-6-(3-methoxyphenyl)pyrimidine
- 2-Amino-4-[3
- Wnt agonist 1 hydrochloride
- BML-284 (Wnt agonist 1)
- Wnt Agonist I in DMSO - CAS 853220-52-7 - Calbiochem
- Wnt Agonist - CAS 853220-52-7 - Calbiochem
- CS-2376
- BML-284 (BML 284
- Wnt Agonist I
- Wnt Agonist
- N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine
- Wnt agonist 1 (BML-284)
- 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine hydrochloride
- BML-284
- Wnt agonist 1
- N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride
- CID 11210285 hydrochloride
- AMBMP