硫培南
|
|
|
- CAS号:
- 120788-07-0
- 英文名:
- Sulopenem
- 英文别名:
- CP-70429;Sulopenem;CP-65207-S;Sulopenem USP/EP/BP;(S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide;(5R,6S)-6-((R)-1-hydroxyethyl)-3-(((1R)-1-oxidotetrahydrothiophen-3-yl)thio)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)-
- 中文名:
- 硫培南
- 中文别名:
- 硫培南;硫陪南;CP-70,429; CP 70,429; CP70,429; CP-70429; CP 70429; CP70429; SULOPENEM
- CBNumber:
- CB81116702
- 分子式:
- C12H15NO5S3
- 分子量:
- 349.45
- MOL File:
- 120788-07-0.mol
|
|
|
硫培南化学性质
-
沸点:
-
693.1±55.0 °C(Predicted)
-
|
-
密度:
-
1.74±0.1 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
酸度系数(pKa):
-
3.88±0.40(Predicted)
-
|
硫培南性质、用途与生产工艺
硫培南是一种具有口服活性的肠胃外青霉烯类抗生素，对革兰氏阳性菌和革兰氏阴性菌具有广谱活性。它可用于尿路感染和腹腔内感染的研究，它对铜绿假单胞菌和嗜黄单胞菌的嗜麦芽孢杆菌无效。
MIC: 0.015-0.12 µg/mL (
E. coli
)
Sulopenem has the potential for uncomplicated and complicated urinary tract infections and intra-abdominal infections treatment, including multidrug-resistant (MDR) infections and infections attributable to quinolone-nonsusceptible and/or extended-spectrum β-lactamase (ESBL)-producing Gram-negative bacilli.
Sulopenem inhibits the growth of most isolates of aerobic and anaerobic Gram-positive and Gram-negative bacteria, including methicillin-susceptible
Staphylococcus aureus
,
Streptococcus pneumoniae
(penicillin-susceptible and -resistant isolates), group A and B β-hemolytic streptococci,
Listeria monocytogenes
,
Enterobacteriaceae
,
Haemophilus influenzae
, and
Moraxella catarrhalis
but excluding
P. aeruginosa
and
Stenotrophomonas maltophilia
, at a concentration of ≤1 μg/mL.
The protective effects of Sulopenem in murine experimental systemic infections are superior to those of Imipenem/Cilastatin. In murine experimental mixed infection with
Escherichia coli
and
Bacteroides fragilis
, Sulopenem has lower ED
50
. In guinea pigs experimental lung infection with
Klebsiella pneumoniae
, Sulopenem is more effective than CZON or Cefotiam.
硫培南
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-105284 | Sulopenem | | 1 mg | 1818元 |
| 2024/04/30 | HY-105284 | 硫培南
Sulopenem | 120788-07-0 | 5mg | 4000元 |
硫培南
生产厂家
全球有 45家供应商
硫培南国内生产厂家
120788-07-0, 硫培南 相关搜索:
- API
- 医药原料
- C12H15NO5S3
- CP-70,429; CP 70,429; CP70,429; CP-70429; CP 70429; CP70429; SULOPENEM
- 硫培南
- 硫陪南
- 120788-07-0
- (5R,6S)-6-((R)-1-hydroxyethyl)-3-(((1R)-1-oxidotetrahydrothiophen-3-yl)thio)-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- Sulopenem USP/EP/BP
- 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-, (5R,6S)-
- (5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[[(1R,3S)-tetrahydro-1-oxido-3-thienyl]thio]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
- Sulopenem
- CP-70429
- CP-65207-S
- (S)-3-[[(5R)-2-Carboxy-6β-[(R)-1-hydroxyethyl]-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]tetrahydrothiophene 1-oxide