硫坎酮
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- CAS号:
- 479-50-5
- 英文名:
- lucanthone
- 英文别名:
- Lucantona;lucanthone;Lycanthone;Lucanthonum;Autophagy,inhibit,Lucanthone,Inhibitor;1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one;1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one;9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
- 中文名:
- 硫坎酮
- 中文别名:
- 硫坎酮;硫蒽酮;甲硫蒽酮;甲硫恩酮;APE-1抑制剂(LUCANTHONE);1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮;1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮
- CBNumber:
- CB8875332
- 分子式:
- C20H24N2OS
- 分子量:
- 340.48
- MOL File:
- 479-50-5.mol
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硫坎酮化学性质
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熔点:
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64.5°C
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沸点:
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512.4±50.0 °C(Predicted)
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密度:
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1.0915 (rough estimate)
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折射率:
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1.5950 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 25 mg/mL (73.43 mM)
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酸度系数(pKa):
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10.00±0.25(Predicted)
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硫坎酮性质、用途与生产工艺
Lucanthone是新型的自噬抑制剂，也是可用于口服的DNA嵌入剂、DNA修复酶APE1的抑制剂。
Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC
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of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.
硫坎酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | S6471 | 硫坎酮
Lucanthone | 479-50-5 | 2mg | 876.63元 |
| 2024/04/30 | HY-B2098 | Lucanthone | | 10 mM * 1 mLin DMSO | 1408元 |
479-50-5, 硫坎酮 相关搜索:
- 药靶配体
- 标准品
- 细胞生物学试剂
- 1-((2-(二乙氨基)乙基)氨基)-4-甲基-9H-硫杂蒽-9-酮
- 甲硫恩酮
- APE-1抑制剂(LUCANTHONE)
- 硫坎酮
- 硫蒽酮
- 甲硫蒽酮
- 1-((2-(二乙基氨基)乙基)氨基)-4-甲基硫杂蒽-9-酮
- 479-50-5
- Autophagy,inhibit,Lucanthone,Inhibitor
- 9H-Thioxanthen-9-one, 1-[[2-(diethylamino)ethyl]amino]-4-methyl-
- Lucantona
- Lucanthonum
- 1-(2-diethylaminoethylamino)-4-(methyl)thioxanthen-9-one
- Lycanthone
- 1-[[2-(Diethylamino)ethyl]amino]-4-methyl-9H-thioxanthen-9-one
- lucanthone