(4-氯苯硫基)甲叉二膦酸二钠
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- CAS号:
- 149845-07-8
- 英文名:
- TILUDRONIC ACID, DISODIUM SALT
- 英文别名:
- SKELID;SR-41319B;SR 41319G;Unii-bh6m93cia0;Tiludrote disodium;DisodiuM Tiludronate;DisodiumTiludronate>TILUDRONIC ACID, DISODIUM SALT;Disodium (4-chlorophenylthio)methylenediphosphonate;(((4-chlorophenyl)thio)methylene)diphosphonic acid, sodium salt
- 中文名:
- (4-氯苯硫基)甲叉二膦酸二钠
- 中文别名:
- 替鲁膦酸二钠;化合物 T13159;(4-氯苯硫基)甲叉二膦酸二钠
- CBNumber:
- CB9288177
- 分子式:
- C7H10ClNaO6P2S
- 分子量:
- 342.6
- MOL File:
- 149845-07-8.mol
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(4-氯苯硫基)甲叉二膦酸二钠化学性质
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熔点:
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>300°C
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储存条件:
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-20°C Freezer
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溶解度:
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Methanol (Slightly), Water (Slightly)
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形态:
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Solid
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颜色:
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White to Off-White
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Merck:
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14,9441
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(4-氯苯硫基)甲叉二膦酸二钠性质、用途与生产工艺
Tiludronate (Tiludronic Acid) disodium 是一种口服活性双膦酸盐,可以起到骨调节作用。Tiludronate disodium 用于代谢性骨疾病的研究。Tiludronate disodium 是破骨细胞空泡H(+)-ATP酶的有效抑制剂。
The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC
50
=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC
50
=466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC
50
=3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible.
Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content.
(4-氯苯硫基)甲叉二膦酸二钠
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | D4167 | 替鲁膦酸二钠 Disodium Tiludronate | 149845-07-8 | 25mg | 1405元 |
149845-07-8, (4-氯苯硫基)甲叉二膦酸二钠 相关搜索:
- Phosphorylating and Phosphitylating Agents
- Pharmaceuticals
- Intermediates & Fine Chemicals
- 有机磷
- 膦配体
- C7H7ClNa2O6P2S
- 化合物 T13159
- 替鲁膦酸二钠
- (4-氯苯硫基)甲叉二膦酸二钠
- 149845-07-8
- (((4-chlorophenyl)thio)methylene)diphosphonic acid, sodium salt
- Disodium [[(4-Chlorophenyl)thio]methylene]bis(hydrogenphosphonate)
- Tiludrote disodium
- DisodiumTiludronate>
- SR 41319G
- DisodiuM Tiludronate
- Unii-bh6m93cia0
- [[(4-Chlorophenyl)thio]methylene]biphosphonicAcid,DisodiumSalt,SR-41319B,Skelid
- [[(4-CHLOROPHENYL)THIO]METHYLENE]BIPHOSPHONIC ACID, DISODIUM SALT
- TILUDRONIC ACID, DISODIUM SALT
- SKELID
- SR-41319B
- Disodium (4-chlorophenylthio)methylenediphosphonate