Tetrahydrocurcumin

Tetrahydrocurcumin Struktur
36062-04-1
CAS-Nr.
36062-04-1
Englisch Name:
Tetrahydrocurcumin
Synonyma:
tetrahydrocurcuminoids;SabiWhite-;Tetrahydrodiferuloylmethane;3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-;LGB-TCH;HZIV 81-2;Nsc687845;Aids110028;Aids-110028;BioaActive THC
CBNumber:
CB01075566
Summenformel:
C21H24O6
Molgewicht:
372.41
MOL-Datei:
36062-04-1.mol

Tetrahydrocurcumin Eigenschaften

Schmelzpunkt:
95-97 ºC
Siedepunkt:
564.1±45.0 °C(Predicted)
Dichte
1.222
Flammpunkt:
196℃
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
DMSO (Slightly), Methanol (Slightly, Heated)
pka
9.12±0.10(Predicted)
Aggregatzustand
powder
Farbe
Light Yellow to Yellow
BRN 
3485469
Stabilität:
Light Sensitive
InChI
InChI=1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3
InChIKey
LBTVHXHERHESKG-UHFFFAOYSA-N
SMILES
C(C1=CC=C(O)C(OC)=C1)CC(=O)CC(=O)CCC1=CC=C(O)C(OC)=C1
LogP
2.728 (est)

Sicherheit

WGK Germany  3

Tetrahydrocurcumin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tetrahydrocurcumin (THC), the active metabolite of curcumin, is gaining popularity amongst scientist due to its wide spectrum of pharmacological activities, better stability and colourless nature. Tetrahydrocurcumin has a similar structure to that of curcumin. THC lacks the α, β-unsaturated carbonyl moiety in its chemical structure. It is naturally sourced from the roots of Curcuma zedoaria, Zingiber mioga, and Zingiber officinale and has potent antioxidant activity and depigmentation of the skin. THC is being studied for the treatment of cancer and dementia. THC is also known to epigenetically ameliorate mitochondrial dysfunction in brain vasculature during Ischemic Stroke. Tetrahydrocurcumin (THC) has been used as a neuroprotective agent to study its therapeutic potential in improving mitochondrial dysfunction in the ischemic stroke mice model.

Chemische Eigenschaften

Off-white crystalline powder or Yellow Solid, soluble in methanol, ethanol, DMSO and other organic solvents, derived from turmeric bulbs.

Verwenden

Tetrahydrocurcumin is an antioxidant and skin-whitening ingredient. It is a major curcuminoid metabolite of curcumin that has been shown to have protective effects against diabetes and vascular dysfunction via alleviation of oxidative stress.The interest in tetrahydrocurcumin research is increasing because it is superior to curcumin in its solubility in water, chemical stability, bioavailability, and anti-oxidative activity. Curcumin metabolizes into tetrahydrocurcumin by bacterial enzyme NADPH-dependent curcumin reductase in the intestine.

synthetische

Tetrahydrocurcumin can also be chemically synthesized from curcumin by catalytic hydrogenation using PtO2 or palladium as a catalyst.
One gram (1.0 g) of curcumin was dissolved in 20 ml of acetone and placed in a 100-ml glass reactor for reduction, to which was then added 500 mg of activated Raney-nickel catalyst. Subsequently, the atmosphere of the reactor was replaced for hydrogen gas by the routine method. A rubber-made balloon filled with hydrogen gas was arranged on the upper portion of the reactor in order to keep hydrogen gas pressure constant in the reactor by supplying hydrogen gas to make up for the consumed amount of hydrogen gas. The reactor was stirred while maintained at a given temperature in a constant-temperature water bath kept at 30° C. for 2-hour reduction.
After completion of the reaction, the Raney-nickel catalyst was removed from the solution by filtering, which was then evaporated and dried by concentration under reduced pressure and was dissolved again in a small amount of acetone.
Subsequently, the eluate was concentrated and dried under reduced pressure to obtain 674 mg of tetrahydrocurcumin.
Method for making tetrahydrocurcumin and a substance containing the antioxidative substance tetrahydrocurcumin

Definition

ChEBI: Tetrahydrocurcumin is a beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds. It has a role as a metabolite. It is a beta-diketone, a polyphenol and a diarylheptanoid. It derives from a curcumin.

benefits

Tetrahydrocurcumin (ultra pure whitening element) is a natural functional whitening ingredient extracted from the roots of Ginger Curcuma longa. It has strong activity of inhibiting tyrosinase. The whitening effect is better than that of arbutin. It can effectively inhibit the generation of oxygen free radicals and remove the formed free radicals. It has obvious antioxidant, inhibits melanin, repairs freckle, anti-inflammatory activity, blocks the inflammatory process, etc. In addition, tetrahydrocurcumin has potent antioxidant activity and potential anti-aging benefits.

Tetrahydrocurcumin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tetrahydrocurcumin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 371)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+86-19164747840 +86-13119157289
13119157289@163.com China 2971 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 346 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578
sales@hbmojin.com China 12471 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 6000 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 1000 58
Hebei Jingbo New Material Technology Co., Ltd
+8619931165850
hbjbtech@163.com China 1000 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567 +86-17782035140
sales@zhswyy.com China 244 58
airuikechemical co., ltd.
+undefined86-15315557071
sales05@airuikechemical.com China 994 58
Hebei Saisier Technology Co., LTD
+86-18400010335 +86-18034520335
admin@hbsaisier.cn China 938 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 1770 58

36062-04-1()Verwandte Suche:


  • 1,7-bis(4-hydroxy-3-methoxy-phenyl)heptane-3,5-dione
  • Tetrahydrocurcumin
  • TETRAHYDROCURCUMINOID
  • Aids110028
  • Aids-110028
  • Nsc687845
  • TETRAHYDROCURCUMIN(P)
  • TetrahydrocucuMin
  • HZIV 81-2
  • BioaActive THC
  • BioActive Tetrahydrocurcuminoids
  • Fat Soluble Tetrahydrocurcuminoids
  • NanoActive Tetrahydrocurcuminoids
  • Water Soluble Tetrahydrocurcuminoids
  • NanoActive THC
  • Tetrahydrocurcumin, 98%, from Curcuma longa L.
  • Nanoactive tetrahydrocurcuminoids THC
  • NanoLiposomal Tetrahydrocurcuminoids
  • Tetrahydrocurcuminoids (THCs)
  • LGB-TCH
  • Tetrahydrocurcumin 36062-04-1
  • Soluble TETRAHYDROCURCUMINOIDS, Liposomal TETRAHYDROCURCUMINOIDS, TETRAHYDROCURCUMINOIDS NanoEmulsion, NanoActive TETRAHYDROCURCUMINOIDS
  • Tetrahydro Curcumin (Mixture of Tautomeric Isomers)
  • Cosmetic use Tetrahydrocurcuminoids
  • etrahydrocurcumin
  • 36062-04-1 TETRAHYDROCURCUMIN
  • Nanoactive Tetrahydrocurcumin (THC)
  • High Purity Tetrahydrocurcumin
  • High Quality Tetrahydrocurcumin
  • SabiWhite-
  • 3,5-Heptanedione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-
  • Tetrahydrodiferuloylmethane
  • tetrahydrocurcuminoids
  • 4-hydrocurcumin
  • Tetrahydrocurcumin 95%
  • Tetrahydrocurcumin95%
  • 36062-04-1
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • 36062-04-1
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