Oxaprozin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
Oxaprozin is a non-steroidal antiinflammatory agent indicated for use in various
forms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. A long
T
1/2 allows once/twice daily dosing. Structurally it is somewhat unique, being a 3-
substituted, rather than a 2-substituted propionic acid.
Chemische Eigenschaften
White Solid
Verwenden
Oxaprozin is an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).
Definition
ChEBI: A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthrit
s and rheumatoid arthritis.
Indications
Oxaprozin (Daypro) is approved for the treatment
of osteoarthritis and rheumatoid arthritis. Its long halflife
allows for once daily dosing.The most frequently reported
adverse effects of this drug are nausea, vomiting,
and dyspepsia.
Allgemeine Beschreibung
Oxaprozin, 4,5-diphenyl-2-oxazolepropionic acid (Daypro),differs from the other members of this group in being anarylpropionic acid derivative. It shares the same propertiesand side effects of other members in this group. It is indicatedfor the short- and long-term management of OA andRA, administered as a once-daily dose of 600- to 1,200-mgdose because of its long duration of action.
Pharmakokinetik
Oxaprozin is well absorbed (100%) following oral administration, but maximum plasma concentrations are not reached
until 3 to 5 hours following ingestion. Oxaprozin is an anti-inflammatory agent possessing a rapid onset of action and
a prolonged duration of action. In both the carrageenan raw paw edema assay and analgetic tests, it was equipotent
with aspirin. Oxaprozin has been associated with the appearance of rash and/or mild photosensitivity. Some patients
experience an increased incidence of rash on sun-exposed skin during clinical testing.
Sicherheitsprofil
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An anti-inflammatory agent. When heated to decomposition it emits toxic fumes of NOx.
Oxaprozin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
