2-(N-Methyl-p-toluidino)ethanol

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Struktur
2842-44-6
CAS-Nr.
2842-44-6
Bezeichnung:
2-(N-Methyl-p-toluidino)ethanol
Englisch Name:
N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE
Synonyma:
FirstCure MHPT;2-(N-Methyl-p-toluidino);HYDROXYETHYL METHYLTOLUIDINE;Hydroxyethyl methyltolylamine;2-(N-methyl-p-toluidino)ethanol;2-(Methyl(p-tolyl)aMino)ethanol;N-methyl-hydroxyethyl-p-toluidine;2-(N-Methyl-N-4-tolylamino)ethanol;2-(N-methyl-N-p-tolylamino)ethanol;2-(Methyl(p-tolyl)amino)ethan-1-ol
CBNumber:
CB2158428
Summenformel:
C10H15NO
Molgewicht:
165.23
MOL-Datei:
2842-44-6.mol

2-(N-Methyl-p-toluidino)ethanol Eigenschaften

Siedepunkt:
152-154 °C(Press: 10 Torr)
Dichte
1.047±0.06 g/cm3(Predicted)
Dampfdruck
0.062-0.115Pa at 20-25℃
storage temp. 
Sealed in dry,Room Temperature
Aggregatzustand
Liquid:viscous
pka
14.69±0.10(Predicted)
LogP
2.2 at 25℃ and pH6
EPA chemische Informationen
Ethanol, 2-[methyl(4-methylphenyl)amino]- (2842-44-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2933599590
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2-(N-Methyl-p-toluidino)ethanol Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE is an amine organic compound, which can be used as intermediate in organic synthesis.

Synthese

Add reactant (0.2 mmol, 1.0 equiv), THF (2.0 mL) and CH2Br2 (0.6 mmol, 3.0 equiv) to a flame-dried 10 mL Schlenk tube in a glove box. Seal and take out of the glove box. Cool the reaction mixture to -78°C. Add nBuLi (0.56 mmol, 2.8 equiv) dropwise under N2 atmosphere within 3minutes. Stir the reaction at -78°C for 30 minutes and add ZnCl2 (0.1 mL, 0.5equiv, 1.0 M in Et2O). Allow the mixture to warm to room temperature and stir for 1 hour. Cool the mixture to 0°C. Add a premixture of H2O2 (30% in H2O, 0.5 mL) and NaOH (2.0 M, 1.0 mL). Stir the mixture at room temperature for another 1 hour and dilute with water (20 mL). Extract with DCM (30 mL x 2) and dry over Na2SO4. Filter and concentrate under vacuum. Purify the crude product by silica gel flash column chromatography to obtain product. 1H NMR (CDCl3, 500 MHz) δ 7.08 (d, J = 8.4 Hz, 2H), 6.78 (d, J = 8.4 Hz,2H), 3.80 (t, J = 5.6 Hz, 2H), 3.43 (t, J = 5.4 Hz, 2H), 2.93 (s, 3H), 2.28 (s, 3H), 2.01 (brs, 1H). 13C NMR (CDCl3, 125 MHz) δ 148.3, 129.8, 127.1, 114.0, 60.1, 56.2, 39.1, 20.4.
synthetic method of N-(2-hydroxyethyl)-N-methyl-4-toluidine Fig The synthetic method of N-(2-hydroxyethyl)-N-methyl-4-toluidine

2-(N-Methyl-p-toluidino)ethanol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(N-Methyl-p-toluidino)ethanol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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2842-44-6(2-(N-Methyl-p-toluidino)ethanol)Verwandte Suche:


  • N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE
  • 2-(N-methyl-p-toluidino)ethanol
  • N-Methyl-N-hydroxyethyl-P-toluidine
  • N-(2-Hydroxyethyl)-N-methyl-p-toluidine
  • 2-[Methyl(4-methylphenyl)amino]ethanol
  • 2-(N-Methyl-N-4-tolylamino)ethanol
  • FirstCure MHPT
  • N-Methyl-N-(2-hydroxyethyl)-p-toluidine
  • 2-(Methyl(p-tolyl)aMino)ethanol
  • 2-(N-methyl-N-p-tolylamino)ethanol
  • N-(2-HYDROXYETHYL)-N-METHYL-PARA-TOLUIDINE(MPHT)
  • N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE(MHPT)
  • Hydroxyethyl methyltolylamine
  • (5S,8R,9S,10S,13S,14S,17R)-17-ethynyl-3,3-difluoro-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
  • 2-(N-Methyl-p-toluidino)
  • Ethanol, 2-[methyl(4-methylphenyl)amino]-
  • N-methyl-hydroxyethyl-p-toluidine
  • HYDROXYETHYL METHYLTOLUIDINE
  • 2842-44-6 N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE
  • 2-(Methyl(p-tolyl)amino)ethan-1-ol
  • 2842-44-6
  • 42-44-6
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