Erlotinib hydrochloride
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- CAS-Nr.
- 183319-69-9
- Englisch Name:
- Erlotinib hydrochloride
- Synonyma:
- ERLOTINIB HCL;Tarceva;ErL;Erlotinib, Hydrochloride Salt;CS-491;OSI 774;RG-1415;CP 358774;NSC718781;RO-0508231
- CBNumber:
- CB2285915
- Summenformel:
- C22H24ClN3O4
- Molgewicht:
- 429.9
- MOL-Datei:
- 183319-69-9.mol
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Erlotinib hydrochloride Eigenschaften
- Schmelzpunkt:
- 223-225°C
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- Löslichkeit
- Soluble in DMSO (up to 18 mg/ml with warming).
- Aggregatzustand
- Yellow powder.
- pka
- pKa (25°): 5.42
- Farbe
- White or off-white
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C22H23N3O4.ClH/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22;/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25);1H
- InChIKey
- GTTBEUCJPZQMDZ-UHFFFAOYSA-N
- SMILES
- C12C=C(OCCOC)C(OCCOC)=CC=1N=CN=C2NC1=CC=CC(=C1)C#C.Cl
- CAS Datenbank
- 183319-69-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
24/25 |
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| HS Code |
29335990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Erlotinib hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Off-White Solid
Verwenden
Erlotinib hydrochloride (V), a quinazoline derived small
molecule inhibitor of epidermal growth factor receptor
(EDGFR) tyrosine kinase, was approved in November,
2004, for the treatment of advanced or metastatic non-smallcell
lung cancer. It belongs to the same class as gefitinib,another quinazoline approved for treatment of advanced lung
cancer, but with improved pharmacokinetic properties. The molecule was originated by Pfizer and development
initiated in collaboration with OSI, which assumed full
rights to the drug when Pfizer merged with Warner Lambert.
Subsequently, Genentech/Roche went into licensing
agreement with OSI to develop and market the drug in the
US and Worldwide.
Definition
ChEBI: A quinazoline hydrochloride compound having a (3-ethynylphenyl)amino group at the 4-position and two 2-methoxyethoxy groups at the 6- and 7-positions.
Allgemeine Beschreibung
Erlotinib is available as 25-, 100-, and 150-mg tablets fororal administration and is used after failure of first-linetherapy in metastatic NSCLC and as first-line therapy incombination with gemcitabine in the treatment of metastaticpancreatic cancer, and in treating malignant gliomas.The structural similarity to gefitnib imparts similar pharmacokineticbehavior with bioavailability of 60% and proteinbinding of 93%. The agent is extensively metabolizedprimarily by CYP3A4. Three major metabolic pathwayshave been identified, involving oxidative-O-demethylationof the side chains followed by further oxidation to give thecarboxlic acids, oxidation of the acetylene functionalityto give a carboxylic acid, and aromatic hydroxylation ofthe phenyl ring para to the electron-donating nitrogen. Themetabolites are primarily eliminated in the feces, and theterminal half-life is 36 hours.The major toxicities seenwith the agent are dose-limiting skin rash and diarrhea.Other common adverse effects include shortness of breath,fatigue, and nausea.
Erlotinib hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Erlotinib hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 740)Lieferanten
183319-69-9()Verwandte Suche:
- ERLOTINIB HCL SALT
- ERLOTINIB HCL SALT :TARCEVA
- N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva
- N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine
- [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
- Tarceva Hydrochloride See E625000
- 6,7-Bis(2-methoxyethoxy)-4-(3-ethynylanilino)quinazoline hydrochloride
- Erlotinib hydrochloride
- N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
- Erlotinib HCl(TINIBS)
- erlotinib hydorchloride
- 6,7-BIS(2-METHOXYETHOXY)-4-(3-ETHYNYLANILINO)QUINAZOLINE HCL
- Erlotonid HCl
- 6,7-Bis(2-methoxyethoxy)-4-(3-
- 21 Erlotinib hydrochloride and Intermediate
- -(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
- Erlotinib, Hydrochloride (Tarceva Hydrochloride)
- Tarceva Hydrochloride (Erlotinib Hydrochloride)
- Erlotinib Hydrochloride (Tarceva)
- Erlotinib, OS-774
- 4-(m-Ethynylanilino)-6,7-bis(2-methoxyethoxy)quinazoline monohydrochloride
- Tarceva (Erlotinib Hydrochloride)
- 4-QuinazolinaMine, n-(3-ethynylphenyl)-6,7-bis(2-Methoxyethoxy)-, hydrochloride
- Erlotinib HCL and InterMediate
- 4-QuinazolinaMine,N-(3-ethynylphenyl)-6,7-bis(2-Methoxyethoxy)-,hydrochloride(1:1)
- [6,7-Bis(2-Methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)aMine Hydrochloride
- CP 358774
- N-(3-Ethynylphenyl)-6,7-bis(2-Methoxyethoxy)-4-quinazolinaMine Hydrochloride
- OSI 774
- NSC718781
- OSI774;CP-358774;TARCEVA;NSC718781
- [6,7-Bis-(2-Methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-aMine.HCl
- N-(3-Ethynylphenyl)-6,7-bis(2-Methoxyethoxy)quinazolin-4-aMine hydrochloride
- Erlotinib Hydrochlorid
- Erlotinib-d6 HCl
- Erlotinib hydrochloride (SynonyMs CP-358774, OSI-774, NSC 718781)
- CP-358774-01
- RG-1415
- RO-0508231
- Erlotinib HCl (OSI-744)
- Erlotinib hydrochloride, 98.5%
- Tarceva, CP-358774
- Erlotinib Hydrochloride WS
- NSC 718781) HCl
- Erlotinib hydrochloride N-(3-Ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine hydrochloride
- Erlotinib HCl, >=99%
- Erlotinib hydrochlroide
- Erlotinib impurity O
- Erlotinib (OSI-744) HCl
- Erlotinib Hcl(CP-358)
- N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quizolin-4-amine
- CS-491
- Erlotinib-11
- Erlotinib Hydrochloride iMpurity 10
- Erlotinib (OSI-744) hydrochloride
- otinib hydrochL
- Erlotinib hydrochloride USP/EP/BP
- erlotinib high quali
