Lactulose
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- CAS-Nr.
- 4618-18-2
- Bezeichnung:
- Lactulose
- Englisch Name:
- Lactulose
- Synonyma:
- Cholac;lactulosa;Piarle;Enulose;cephulac;Duphalac;chronulac;Constilac;Constulose;Lactulosum
- CBNumber:
- CB2779607
- Summenformel:
- C12H22O11
- Molgewicht:
- 342.3
- MOL-Datei:
- 4618-18-2.mol
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Lactulose Eigenschaften
- Schmelzpunkt:
- ~169 °C (dec.)
- Siedepunkt:
- 397.76°C (rough estimate)
- alpha
- -47 º (C=5, H2O, 12HR)
- Dichte
- 1,32g/cm
- Brechungsindex
- 1,45-1,47
- storage temp.
- Refrigerator
- Löslichkeit
- Freely soluble in water, sparingly soluble in methanol, practically insoluble in toluene.
- Aggregatzustand
- Powder
- pka
- 11.67±0.20(Predicted)
- Farbe
- White to almost white
- Optische Aktivität
- [α]20/D 48±2°, 24 hr, c = 1% in H2O
- Wasserlöslichkeit
- 76.4 G/100 ML (30 ºC)
- Merck
- 5346
- BRN
- 93773
- BCS Class
- 2?
- InChIKey
- PFCRQPBOOFTZGQ-VZXVHDRGSA-N
- LogP
- -2.885 (est)
- CAS Datenbank
- 4618-18-2(CAS DataBase Reference)
- EPA chemische Informationen
- D-Fructose, 4-O-.beta.-D-galactopyranosyl- (4618-18-2)
Lactulose Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Powder
Verwenden
Lactulose is is a synthetic, non-digestible sugar used in the treatment of chronic constipation; laxative.
Definition
ChEBI: A synthetic galactosylfructose disaccharide used in the treatment of constipation and hepatic encephalopathy.
Indications
Osmotic laxatives (e.g., lactulose, sorbitol) are poorly
absorbed or nonabsorbable compounds that draw additional
fluid into the GI tract. Lumen osmolality increases,
and fluid movement occurs secondary to osmotic
pressure. Lactulose is a synthetic disaccharide
that is poorly absorbed from the GI tract, since no
mammalian enzyme is capable of hydrolyzing it to its
monosaccharide components. It therefore reaches the
colon unchanged and is metabolized by colonic bacteria
to lactic acid and to small quantities of formic and acetic
acids.
Clinical Use
Lactulose is used in the
treatment of hepatic encephalopathy.
Nebenwirkungen
Since lactulose does contain galactose, it is contraindicated
in patients who require a galactose-free
diet. Metabolism of lactulose by intestinal bacteria may
result in increased formation of intraluminal gas and
abdominal distention.
läuterung methode
Crystallise lactulose from MeOH or 50% MeOH. It mutarotates from [] D 20 -11.9o to –50.7o (c 1, H2O). [Montgomery & Hudson J Am Chem Soc 32 2101, 2104 1930, Beilstein 17 III/IV 3094, 17/7 V 214.] NMR in Me2SO at 24o shows 0% -pyranose, 27% -pyranose, 20% -furanose and 52% -furanose fforms [Angyal Adv Carbohydr Chem 42 15 1984].
Lactulose Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lactulose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 406)Lieferanten
4618-18-2(Lactulose)Verwandte Suche:
- MLS-50
- 4-0-beta-d-galactopyranosyl-d-fructose
- 4-o-beta-d-galactopyranosyl-d-fructos
- 4-o-beta-d-galattopiranosil-d-fruttofuranosio
- 4-O-D-Galactopyranosyl-D-fructose
- 4-O-β-D-Galactopyranosyl-D-fructose, 4-O-β-D-Galactopyranosyl-D-fructofuranose
- lactutose syrup
- Caloryl
- Lagnos
- Liforos
- 4-O-beta-D-Galactopyranosyl-alpha-D-fructose
- LACTULOSE(RG)
- Lactulose,4-O-β-D-Galactopyranosyl-D-fructofuranose, 4-O-β-D-Galactopyranosyl-D-fructose
- Lactulose (1 g)
- 4-O-β-D-Glactosyl-D-fructose
- Laevilac
- Lactulose (750 mg)
- Isomerized lactose syrup
- (3S,4R,5R)-1,3,5,6-tetrahydroxy-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)hexan-2-one
- [UL-13C12]lactulose
- D-Fructose, 4-O-b-D-galactopyranosyl-
- Lactulose for peak identification
- bifiteral
- d-fructofuranos
- d-lactulose
- isolactose
- Lactuloseliquid
- lactulosum(latin)
- laevolac
- lattulosio
- LACTULOSE CRYSTALLINE
- LACTULOSE ABOUT 98%
- LACTULOSE, >95%
- Lactulose, 50 wt.% solution in water
- Lactulose, 99+%
- 4-O-D-Galactopyranosyl-D-fructofuranose Cephulac
- Lactulos
- D-Fructose, 4-O-.beta.-D-galactopyranosyl-
- LACTULOSE,POWDER
- LACTULOSESOLUTION,USP
- 4-O-b-D-galactopyranosyl-D-fructofuranose
- LACTULOSE
- 4-O-β-D-Galactopyranosyl-D-fructofuranose
- LACTULOSE MIN 85%
- LACTULOSE USP
- 4-O-BETA-D-GALACTOPYRANOSYL-D-FRUCTOFURANOSE
- 4-O-BETA-D-GALACTOPYRANOSYL-D-FRUCTOSE
- ruguotang
- D-Fructose, 4-O-β-D-galactopyranosyl-
- Lactulose RS
- Lactulose CRS
- Lactulose USP/EP/BP
- Lactulose Impurity 18
- 4-O-β-D-Galactopyranosyl-D-fructose
- Lactulose(solid)
- Lactulose, ≥98%
- LactuloseQ: What is
Lactulose Q: What is the CAS Number of
Lactulose Q: What is the storage condition of
Lactulose Q: What are the applications of
Lactulose
- (2S,3S,4S,5R,6R)-2-[(2R,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
