N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36:Reizt die Augen.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
Diethylenetriaminepentaacetic acid is a solid.
Verwenden
Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
Vorbereitung Methode
Pentetic acid is a pentaacetic acid triamine formed during the
preparation of the amino carboxylic acid and its salt.
Allgemeine Beschreibung
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Pharmazeutische Anwendungen
Pentetic acid is mainly used as a chelating agent in the preparation
of imaging and contrast agents for radionuclide and magnetic
resonance imaging.It is also used as a carrier excipient for
neutron-capture isotopes in, for example, radiotherapy.Pentetic
acid–isotope complexes have also been considered as model active
substances in scintigraphic imaging studies.Pentetic acid has been
used to chelate metal ions to reduce formation of reactive oxygen
species during lyophilization.
Sicherheitsprofil
Moderately toxic by
intraperitoneal route. When heated to
decomposition it emits toxic fumes of NOx.
Sicherheit(Safety)
Pentetic acid is used in intrathecal and intravenous injection
preparations. The pure form of pentetic acid is moderately toxic
by the intraperitoneal route.
LD
50 (mouse, IP): 0.54 g/kg
LD
50 (mouse, oral): 4.84 g/kg
Lager
The activity of pentetic acid as a chelating agent may cause
unwanted effects in formulations containing metal ions. The desired
chelate may be displaced by other ions from the formulation.
läuterung methode
Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
Inkompatibilitäten
The activity of pentetic acid as a chelating agent may cause
unwanted effects in formulations containing metal ions. The desired
chelate may be displaced by other ions from the formulation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (intrathecal and
intravenous injections). Included in intravenous and intra-articular
injections licensed in the UK.
N-Carboxymethyliminobis(ethylennitrilo)tetraessigsure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
