AZD 3759
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- CAS-Nr.
- 1626387-80-1
- Englisch Name:
- AZD 3759
- Synonyma:
- azd3579;AZD3759;CS-1596;AZD-3759;AZD 3759;HY-18750;AZD37591;zorifertinib.;zorifertinibum;AZD3759 Powder
- CBNumber:
- CB53041786
- Summenformel:
- C22H23ClFN5O3
- Molgewicht:
- 459.9
- MOL-Datei:
- 1626387-80-1.mol
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AZD 3759 Eigenschaften
- Siedepunkt:
- 571.4±50.0 °C(Predicted)
- Dichte
- 1.358±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- Löslichkeit
- ≥23 mg/mL in DMSO; insoluble in H2O; ≥8.32 mg/mL in EtOH with ultrasonic
- Aggregatzustand
- solid
- pka
- 6.71±0.40(Predicted)
- InChIKey
- MXDSJQHFFDGFDK-CYBMUJFWSA-N
- SMILES
- N1(C(OC2C(OC)=CC3C(C=2)=C(NC2=CC=CC(Cl)=C2F)N=CN=3)=O)CCN(C)C[C@H]1C
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
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P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P305+P351+P338 |
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AZD 3759 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
AZD3759 is an EGFP inhibitor (Epidermal growth factor receptor tyrosine kinase inhibitor) with blood brain barrier (BBB) penetration. It has the potential for the treatment of non-small cell lung cancer (NSCLC), with brain metastases (BM) and leptomengingeal metastases (LM) since this type of cancer often contain a lot of activating mutations of the epidermal growth factor receptor (EGFR). It has excellent capability of penetrating the blood brain barrier to reach the central nervous system.
Einzelnachweise
Zeng, Qingbei, et al. "Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI)." Journal of Medicinal Chemistry 58.20(2015):8200.
Yang, Zhenfan, et al. "Abstract LB-217: Antitumor activities of AZD3759, a novel EGFR inhibitor with excellent penetration across central nervous system (CNS), in preclinical animal models." Cancer Research 76.14 Supplement(2016):LB-217-LB-217.
Xiong, S., et al. "Determination of AZD3759 in rat plasma and brain tissue by LC-MS/MS and its application in pharmacokinetic and brain distribution studies." Journal of Pharmaceutical & Biomedical Analysis140(2017):362-366.
AZD 3759 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
AZD 3759 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 261)Lieferanten
1626387-80-1()Verwandte Suche:
- AZD 3759
- AZD3759
- AZD-3759
- (2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester
- HY-18750
- azd3579
- 1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-
- 1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-[(3-CHLORO-2-FLUOROPHENYL)AMINO]-7-METHOXY-6-QUINAZOLINYL ESTER
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb
- (R)-4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 2,4-dimethylpiperazine-1-carboxylate
- zorifertinibum
- AZD3759; AZD-3759; AZD 3759; ZORIFERTINIBUM; ZORIFERTINIB.
- zorifertinib.
- 4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl 1-piperazinecarboxylic acid 2,4-dimethyl ester
- 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carboxylate
- CS-1596
- AZD-3759;AZD 3759;;AZD3759
- AZD37591
- 4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (R)-2,4-dimethylpiperazine-1-carboxylate
- High Purity Azd 3759 CAS:
- High Purity Azd3759/Azd-3759 CAS 1626387-80-1 with Steady Supply
- Anti Cancer Azd3759, High Purity
- AZD3759 Powder
- Zorifertinib (AZD3759
- TIANFU CHEM---AZD 3759
- 4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl (2R)-2,4-dimethyl-1-piperazinecarboxylate
- AZD3759 AZD-3759
- 1626387-80-1
- 626387-80-1
- C22H23ClFN5O3
- API