Exemestane
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- CAS-Nr.
- 107868-30-4
- Englisch Name:
- Exemestane
- Synonyma:
- AROMASIN;EXALAMIDE;Exemestan;ExeMestane(AroMasin);EXE;ROMASIN;Isimetan;PNU155971;FCE-24304;ExeMestine
- CBNumber:
- CB5760314
- Summenformel:
- C20H24O2
- Molgewicht:
- 296.4
- MOL-Datei:
- 107868-30-4.mol
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Exemestane Eigenschaften
- Schmelzpunkt:
- 155.13°C
- Siedepunkt:
- 453.7±45.0 °C(Predicted)
- Dichte
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Optische Aktivität
- [α]/D +250 to +300°, c = 1 in methanol
- InChI
- InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
- InChIKey
- BFYIZQONLCFLEV-DAELLWKTSA-N
- SMILES
- C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C
- CAS Datenbank
- 107868-30-4(CAS DataBase Reference)
Exemestane Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Exemestane was launched in US and other countries for the treatment of estrogendependent
tumors and postmenopausal breast cancer. It is a novel steroidal compound
structurally related to the natural substrate for the biosynthesis of estrogen,
androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien-
17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an
irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related
sustained suppression of serum estrogen and minimal endocrine activity. It is the first
steroidal representative of the third-generation of orally active aromatase inhibitors with a
highly potent and selective mechanism of action, displaying good tolerability and safety
profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan
administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing
anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally
advanced or metastatic disease. In addition, it may also have potential for breast cancer
prevention.
Chemische Eigenschaften
white to light yellow crystal powder
Verwenden
Labeled Exemestane, intended for use as an internal standard for the quantification of Exemestane by GC- or LC-mass spectrometry.
Definition
ChEBI: A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced brea
t cancer.
Allgemeine Beschreibung
Exemestane, 6-methylenandrosta-1,4-diene-3,17-dione (Aromasin), is the first steroid-basedaromatase inhibitor approved for the treatment of breastcancer in the United States. It is a mechanism-based inactivatorthat irreversibly inhibits the enzyme. Plasma estrogenlevels are reduced by 85% to 95% within 2 to 3 days, and effectslast 4 to 5 days. Exemestane does not inhibit any of themajor cytochromes P450 and has essentially no interactionwith steroid receptors, with only a very weak affinity for theAR. The 17β-hydroxyexemestane reduction product, however,has much higher affinity for the AR than the parent(still several fold less than DHT, 0.28% for parent vs. 30%for metabolite). The clinical significance of the affinity islikely minimal because of the low levels of the metaboliteproduced.
Hazard
A reproductive hazard.
Exemestane Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Toluol-4-sulfonsure
Ethanol
Formaldehyd
Tetrahydrofuran
Benzoesure
4,5-Dichlor-3,6-dioxocyclohexa-1,4-dien-1,2-dicarbonitril
oestr-5(10)-en-3,17-dion
Androsta-3,5-dien-17-one, 1,3-di-1-pyrrolidinyl-, (1α)-
Androsta-1,4-diene-3,17-dione, 6-(hydroxymethyl)-, (6α)-
3-Ethoxy-androsta-3,5-dien-17-one
Methylene boldenone
Exemestane Impurity 2
6-Methyleneandrost-4-ene-3,17-dione
Boldenon
Androsta-1,4-dien-3,17-dion
Prasteron
Downstream Produkte
Exemestane Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 569)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
|
Rixing Chemical CO.,LTD.
|
+86-852-57055271 +8613237129059
|
sales@rixingbiz.com |
China |
232 |
58 |
|
Shanghai Longyu Biotechnology Co., Ltd.
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+8619521488211
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info@longyupharma.com |
China |
2524 |
58 |
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Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
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+8615995072465
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sales@xuanmingchem.com |
China |
914 |
58 |
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Zhejiang J&C Biological Technology Co.,Limited
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+1-2135480471 +1-2135480471
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sales@sarms4muscle.com |
China |
10473 |
58 |
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Hong Kong Excellence Biotechnology Co., Ltd.
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|
ada@sh-teruiop.com |
China |
875 |
58 |
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Shanghai Getian Industrial Co., LTD
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+86-15373193816 +86-15373193816
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mike@ge-tian.com |
China |
269 |
58 |
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Sinoway Industrial co., ltd.
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0592-5800732; +8613806035118
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xie@china-sinoway.com |
China |
988 |
58 |
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Hebei Mojin Biotechnology Co., Ltd
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+86 13288715578 +8613288715578
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sales@hbmojin.com |
China |
12835 |
58 |
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Hebei Yanxi Chemical Co., Ltd.
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+8617531190177
|
peter@yan-xi.com |
China |
5858 |
58 |
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Anhui Zhongda Biotechnology Co., Ltd
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+8619956560829
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justine@zhongda-biotech.com |
China |
286 |
58 |
107868-30-4()Verwandte Suche:
- ExeMestane (USP)
- 1,4-Androstadien-3,17-dione-6-Methylene-d2
- (8R,9S,10R,13S,14S)-10,13-Dimethyl-6-methylene-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17(10H,14H)-dione
- ExeMestine
- (8R,9S,10R,13S,14S)-10,13-diMethyl-6-Methylene-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione
- ExeMestane SynonyMs 6-Methylenandrosta-1,4-diene-3,17-dione
- PNU155971
- Exemestane for system suitability
- Exemestance:6-methyleneandrosta-1,4-diene-3,17-dione
- Exemestane D2
- 6-methylenandrosta-1,4-diene-3,17-dione
- 6-METHYLENEANDROSTA-1,4-DIENE-3,17-DIONE
- Exemestance
- 10,13-dimethyl-6-methylidene-7,8,9,10,11,12,13,14,15,16-decahydrocyclopenta[a]phenanthrene-
- EXEMESTANE
- FCE-24304
- Androsta-1,4-diene-3,17-dione, 6-methylene
- 6-Methyleneandrosta-1,4-diene-3,17-dione, FCE-24304, Aromasin
- FCE24304;FCE-24304
- Exemestane(FCE 24304)
- 10,13-dimethyl-6-methylene-7,8,9,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,17-dione
- Exemestane - Aromasin | FCE 24304
- Exemestone
- EXE
- Aromasin/exemestane
- Aromasin CAS 107868-30-4
- Exemestane CRS
- Exemestane for system suitability CRS
- [2H2]-Exemestane
- Aromasin Exeme Acatate?
- Exemestane USP/EP/BP
- Steroids Raw Powder Hormone Exemestane, Aromasin
- Exemestane(USFDA/CEP）
- ROMASIN
- Exemestane (Aromasin,EXE)-1 gram(17)
- ExemestaneQ: What is
Exemestane Q: What is the CAS Number of
Exemestane Q: What is the storage condition of
Exemestane Q: What are the applications of
Exemestane
- Exemestane for system suitability (Y0001756)
- Exemestane 13C D2Q: What is
Exemestane 13C D2 Q: What is the CAS Number of
Exemestane 13C D2 Q: What is the storage condition of
Exemestane 13C D2 Q: What are the applications of
Exemestane 13C D2
- Exemestane D2Q: What is
Exemestane D2 Q: What is the CAS Number of
Exemestane D2 Q: What is the storage condition of
Exemestane D2 Q: What are the applications of
Exemestane D2
- Exemestane (1269050)
- ExeMestane(AroMasin)
- Exemestan
- AROMASIN
- EXALAMIDE
- Exemestane 107868-30-4
- Aromasin / Exemestan / Exemestane
- Aromasin, or Exemestane
- 17b-Hydroxy Exemestane-d3 17-O-b-D-Glucuronide
- Isimetan
- Aromasin Exemestane 25mg Tablets
- 107868-30-4
- 156-1-31
- 7868-30-4
- 107968-30-4
- C20H24O2
- 2964
- Intermediates & Fine Chemicals
- Pharmaceuticals
