Atractylenolide-1

Atractylenolide-1 Struktur
73069-13-3
CAS-Nr.
73069-13-3
Englisch Name:
Atractylenolide-1
Synonyma:
Extracted oil;Dictyolactone I;Atracylenolide I;ATRACTYLENOLIDE-1;Atractylenolide Ⅰ;8,9-Dehydroasterolide;Atractylenolide I, >99%;Eudesma-4(15),7(11),8-trien-12-olide;Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one
CBNumber:
CB5847745
Summenformel:
C15H18O2
Molgewicht:
230.3
MOL-Datei:
73069-13-3.mol

Atractylenolide-1 Eigenschaften

Schmelzpunkt:
121-123 °C(Solv: ligroine (8032-32-4))
Siedepunkt:
405.0±44.0 °C(Predicted)
Dichte
1.12
Flammpunkt:
170℃
storage temp. 
2-8°C
Löslichkeit
methanol: soluble1mg/mL, clear, colorless
Aggregatzustand
powder
Farbe
White
InChIKey
ZTVSGQPHMUYCRS-SWLSCSKDSA-N

Sicherheit

WGK Germany  3

Atractylenolide-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Atractylenolide I is a sesquiterpene that has been found in the rhizomes of A. macrocephala and has diverse biological activities, including anti-inflammatory, anti-angiogenic, anti-tumor, and antidepressant properties. It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, as well as inducible nitric oxide synthase (iNOS) activity, in murine peritoneal macrophages (IC50s = 23.1, 41, and 67.3 μM, respectively). Atractylenolide I reduces pouch fluid weight, inflammatory cell count, granuloma weight, and vascular index (ID50s = 24.18, 19.46, 14.44, and 15.15 mg/kg, respectively) in a mouse air pouch granuloma model induced by Freund''s complete adjuvant (FCA). It also reduces the number of microvessels in the air pouch wall by 58.27% when administered at a dose of 20 mg/kg and reduces the blood levels of TNF-α, IL-1β, IL-6, VEGF, placenta growth factor (PlGF), and bFGF in a dose-dependent manner in a mouse model of FCA-induced granuloma. Atractylenolide I inhibits the growth of T-24, 5637, RT4, and 253J bladder cancer cells in vitro (IC50s = 12.8-63.7 μM) and reduces tumor growth in T-24 and 253J mouse xenograft models in a dose-dependent manner. In a mouse model of depression induced by chronic unpredictable mild stress, atractylenolide I reverses stress-induced decreases in hippocampal levels of serotonin (5-HT; ) and norepinephrine and reduces immobility time in the forced swim and tail suspension tests in a dose-dependent manner, indicating antidepressant-like activity.

Atractylenolide-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Atractylenolide-1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 211)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 1000 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 15956 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3424 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 3000 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58

  • ATRACTYLENOLIDE-1
  • 3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one
  • Eudesma-4(15),7(11),8-trien-12-olide
  • 8,9-Dehydroasterolide
  • (4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one
  • Atractylenolide Ⅰ
  • Atractylenolide I, >99%
  • Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-
  • Atracylenolide I
  • Extracted oil
  • Methyl 4-ethyl-6,7-dimethoxy-9H-b-carboline-3-carboxylate
  • STAT,Atractylenolide I,Janus kinase,Inhibitor,JAK,Toll-like Receptor (TLR),inhibit
  • Dictyolactone I
  • 73069-13-3
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