DL-ERYTHRO-DIHYDROSPHINGOSINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
DL-
erythro Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate . Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. This product is a mixture of sphinganine (d18:0) , L-
erythro sphinganine (d18:0) , D-
threo sphinganine (d18:0) , and L-
threo sphinganine (d18:0). [Matreya, LLC. Catalog No. 1324]
Chemische Eigenschaften
White Powder
Verwenden
DL-erythro-Dihydrosphingosine is an inhibitor of PKC (protein kinase C). This compound also blocks PLA2 (phospholipases A2) and the D-sphingosine precursor.
Biologische Aktivität
Protein kinase C inhibitor.
läuterung methode
Purify it by recrystallisation from pet ether/EtOAc or CHCl3. The (±)-N-dichloroacetyl derivative has m 142-144o (from MeOH). [Shapiro et al. J Am Chem Soc 80 2170 1958, Shapiro & Sheradsky J Org Chem 28 2157 1963.] The D-isomer crystallises from pet ether/Et2O and has m 78.5-79o, [] 28 +6o (CHCl3/MeOH, 10:1). [Grob & Jenny Helv Chim Acta 35 2106 1953, Jenny & Grob Helv Chim Acta 36 1454 1953, Beilstein 4 I 448, 4 II 757, 4 III 854, 4 IV 1887.]
DL-ERYTHRO-DIHYDROSPHINGOSINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
