QS11

944328-88-5

CAS-Nr.: 944328-88-5

Englisch Name:: QS11

Synonyma:: QS11;CS-346;BML-WN117;QS11 hydrate;QS11;BML-WN117;Wnt Synergist, QS11;Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem;(S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino);(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol;synergistic,Wnt,regenerative,agonist,signaling,factors,Inhibitor,QS11,inhibit,ADP-ribosylation,QS-11

CBNumber:: CB62517933

Summenformel:: C36H33N5O2

Molgewicht:: 567.69

MOL-Datei:: 944328-88-5.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 73

QS11 Eigenschaften

Siedepunkt:: 852.2±75.0 °C(Predicted)

Dichte: 1.27

storage temp.: Keep in dark place,Sealed in dry,2-8°C

Löslichkeit: Soluble in DMSO

Aggregatzustand: Pale amber solid

pka: 14.46±0.10(Predicted)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H317	Kann allergische Hautreaktionen verursachen.	Sensibilisierung der Haut	Kategorie 1A	Warnung	src="/GHS07.jpg" width="20" height="20" />	P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319	Verursacht schwere Augenreizung.	Schwere Augenreizung	Kategorie 2	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P280, P305+P351+P338,P337+P313P

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

QS11 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

QS11 is an inhibitor of GTPase activating protein of ADP-ribosylation factors (ARFGAPs) that increases activity of ARFs in NIH3T3 cells at a concentration of 1 μM. It activates Wnt/β-catenin activity in a reporter assay using HEK293 cells (EC₅₀ = 0.5 μM). QS11 exhibits synergy with Wnt-3a ligand-conditioned media, inducing a 200-fold increase in reporter activity compared to 40- and 2-fold increases observed with Wnt-3a ligand-conditioned media alone or QS11 treatment alone, respectively. It inhibits ARFGAP1 with an EC₅₀ value of 1.5 μM in an enzyme assay and inhibits the migration of MDA-MB-231 breast cancer cells that overexpress AMAP1, an ARFGAP essential to cellular invasiveness.

Verwenden

QS 11 is a small molecule Wnt synergistic agonist.

QS11 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

QS11 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 73)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
BeiJing Hwrk Chemicals Limted	0757-86329057 18934348241	sales4.gd@hwrkchemical.com	China	14067	55
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5700	66
ChemCell Biomedicine Co.,Ltd.	020-13556033878 2965585218 13556033878	chemcell@hotmail.com	China	369	52

QS11
(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
(betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol
QS11 hydrate
Wnt Synergist, QS11
(S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)
QS 11 (betaS)-beta-[[9-([1,1'-Biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]benzenepropanol
(2S)-2-[2-(Indan-5-yloxy)-9-(1,1′-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol hydrate
Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem
(S)-2-((9-([1,1'-Biphenyl]-4-ylmethyl)-2-((2,3-dihydro-1H-inden-5-yl)oxy)-9H-purin-6-yl)amino)-3-phenylpropan-1-ol
CS-346
BML-WN117
QS11;BML-WN117
Benzenepropanol, β-[[9-([1,1'-biphenyl]-4-ylmethyl)-2-[(2,3-dihydro-1H-inden-5-yl)oxy]-9H-purin-6-yl]amino]-, (βS)-
synergistic,Wnt,regenerative,agonist,signaling,factors,Inhibitor,QS11,inhibit,ADP-ribosylation,QS-11
944328-88-5
C36H33N5O2