NSC 23766 TETRAHYDROCHLORIDE

733767-34-5

CAS-Nr.: 733767-34-5

Englisch Name:: NSC 23766 TETRAHYDROCHLORIDE

Synonyma:: CS-594;CS-1187;NSC 23766;NPEC-caged-(1S;NSC23766;NSC 23766;NSC-23766 free base;NSC 23766 TETRAHYDROCHLORIDE;N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine;4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-;N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride

CBNumber:: CB6504010

Summenformel:: C24H35N7

Molgewicht:: 421.58

MOL-Datei:: 733767-34-5.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 95

NSC 23766 TETRAHYDROCHLORIDE Eigenschaften

storage temp.: Desiccate at RT

Löslichkeit: Soluble in DMSO (50 mg/ml); Water (50 mg/ml)

Aggregatzustand: White powder solid.

Farbe: White

Wasserlöslichkeit: Soluble in water.

Sensitive: Light Sensitive & Hygroscopic

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Sicherheit

NSC 23766 TETRAHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.

Biologische Aktivität

Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC 50 ~ 50 μ M) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and reported to reverse tumor cell phenotyes in prostate cancer cells.

NSC 23766 TETRAHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NSC 23766 TETRAHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 95)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
QINGDAO CARELONGPHARMATECH CO.,LTD	0532-0532-88191853 13061484198	sales@carelongchem.com	China	405	57
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	market@aladdin-e.com	China	25014	65
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7854	58
AdooQ Bioscience CHINA	025-58849295 18951903616;	info@adooq.cn	China	2989	60

733767-34-5()Verwandte Suche:

6-Hydroxy-2,5,7,8-tetramethylchroman-2-carbonsure Chinolin-6-amin

NSC 23766 TETRAHYDROCHLORIDE
N6-[2-[[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO]-6-METHYL-4-PYRIMIDINYL]-2-METHYL-4,6-QUINOLINEDIAMINE TRIHYDROCHLORIDE
NSC 23766
N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride
N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
NSC23766;NSC 23766
CS-1187
CS-594
NSC-23766 free base
4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-
NPEC-caged-(1S
733767-34-5
C24H35N7
C24H35N73HCl
C24H38Cl3N7
Rac1 Inhibitor.
G-Protein
Other enzyme inhibitors and activators