Verteporfin
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- CAS-Nr.
- 129497-78-5
- Englisch Name:
- Verteporfin
- Synonyma:
- BPD-MA;Visudyne;CL 318952;NSC6242;NSC 6242;NSC-6242;VERTEPIRFIN;Verteporfin;Verteprofin;Verteporfen
- CBNumber:
- CB6505794
- Summenformel:
- 2C41H42N4O8
- Molgewicht:
- 1437.61
- MOL-Datei:
- 129497-78-5.mol
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Verteporfin Eigenschaften
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble2mg/mL, clear (warmed)
- Aggregatzustand
- powder
- Farbe
- Black
- Stabilität:
- Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
- InChIKey
- YHNBVDZVUQFVLS-RDSGBMLISA-N
Verteporfin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Verteporfin was introduced in Switzerland as a second-generation photosensitizer for
photodynamic therapy of wet age-related macular degeneration in patients with subfoveal
choroidal neovascularisation. It is constituted of a mixture of two regioisomers resulting
from nonselective monohydrolysis of the methyl tetraester. Upon irradiation with a lowenergy
nonheat-generating laser light of 689nm wavelength, both regioisomeric
benzoporphyrins are responsible for the local generation of singlet oxygen leading to free
radical damage of neovascular endothelial cells in subfoveal lesions of patients with agerelated
macular degeneration. The lipophilic drug is injected i.v. as a liposomal formulation
in order to favor its uptake by plasma lipoproteins and distribution to cells with a high
expression of low density lipoprotein receptors such as tumor and neovascular endothelial
cells. Verteporfin is also being developed for the treatment of other eye diseases, nonmelanoma
skin cancer and psoriasis.
Verwenden
Verteporfin is a photosensitizer that is used in photodynamic therapy (PDT). Verteporfin can accumulate in tumor tissues allowing for 30 to 150 minutes optimal PDT after intravenous administration.
Verteporfin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Verteporfin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 192)Lieferanten
129497-78-5()Verwandte Suche:
- Verteporfin(DB00460)
- Verteprofin
- Verteporfin
- Verteporphin
- 24H,26H-Benzo[b]porphine-9,13-dipropanoic acid, 18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-, monomethyl ester, (4R,4aS)-rel-
- VERTEPIRFIN
- 9-methyl (I)13-methyl (II)trans-(±)- 18-ethenyl- 4,4a-dihydro-3,4 -bis(methoxycarbonyl)- 4a,8,14,19-tetramethyl- 23H,25H-benzo[b]porphine- 9,13- dipropanoate
- (4R,4aS)-rel-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-Benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
- 3-[(23S,24R)-14-Ethenyl-5-(3-methoxy-3-oxopropyl)-22,23-bis(methoxycarbonyl)-4,10,15,24-tetramethyl-25,26,27,28-tetraazahexacyclo[16.6.1.13,6.18,11.113,16.019,24]octacosa-1,3,5,7,9,11(27),12,14,16,18(25),19,21-dodecaen-9-yl]propanoic acid
- VERTEPORFIN (200 MG)
- trans-3,4-Dicarboxy-4,4a-dihydro-4a,8,14,19-tetramethyl-18-vinyl-23H,25H-benzo(b)porphine-9,13-dipropionic acid 3,4,9-trimethyl ester
- (4R,4aS)-18-Ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-24H,26H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester
- Verteporfin (Visudyne)
- Verteporfin USP/EP/BP
- Verteporfin (DB-00460, CL-318952, BPD-MA, BpdMA)
- VerteporfinQ: What is
Verteporfin Q: What is the CAS Number of
Verteporfin Q: What is the storage condition of
Verteporfin Q: What are the applications of
Verteporfin
- Verteporfen
- Verteporfin (1711461)
- N-Diethylformamide
- NSC 6242
- NSC6242
- NSC-6242
- Visudyne
- CL 318952
- BPD-MA
- 23H,25H-Benzo[b]porphine-9,13-dipropanoic acid, 18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-, monomethyl ester, trans-
- Verteporfin,inhibit,CL318952,CL-318952,Yes-associated protein,Autophagy,Apoptosis,Inhibitor,YAP
- Verteporfin (CL 318952)
- 129497-78-5
- C41H42N4O8
- Visudyne
- Inhibitors
- APIs
