Otiloniumbromid
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- CAS-Nr.
- 26095-59-0
- Bezeichnung:
- Otiloniumbromid
- Englisch Name:
- Otilonium bromide
- Synonyma:
- Otilonium;OCTYLONIUM BROMIDE;Spasmomen;SPASMONEN;SP-63;Spasen;Doralin;Menoctyl;Pasminox;Spasmome
- CBNumber:
- CB6712880
- Summenformel:
- C29H43BrN2O4
- Molgewicht:
- 563.58
- MOL-Datei:
- 26095-59-0.mol
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Otiloniumbromid Eigenschaften
- Schmelzpunkt:
- 130-133°C
- storage temp.
- -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly)
- Aggregatzustand
- powder
- Farbe
- white to beige
- CAS Datenbank
- 26095-59-0(CAS DataBase Reference)
Otiloniumbromid Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Otilonium is an inhibitor of L-type (IC
50 = 2.3 μM) and T-type calcium channels (IC
50s = 0.8, 1.1, and 0.4 μM for Ca
v3.1, Ca
v3.2, and Ca
v3.3, respectively). It is also an antagonist of muscarinic acetylcholine receptors (mAChRs; IC
50s = 0.054, 0.4, 0.222, and 0.156 μM for M
1, M
2, M
4, and M
5 muscarinic receptors, respectively) and the platelet activating factor (PAF) receptor (IC
50 = 0.0552 μM). Otilonium inhibits the inward calcium current in isolated rat colonic smooth muscle cells (EC
50 = 885 nM), an effect that can be blocked by the L-type calcium channel inhibitor nifedipine . It inhibits contractions induced by the muscarinic acetylcholine receptor (mAChR) agonist methacholine in isolated circular muscle of the guinea pig proximal colon (IC
50 = 3.7 μM). Otilonium (4 mg/kg) decreases fecal excretion and wet dog shakes and increases the tail withdrawal latency in the tail-flick test in a rat model of opioid withdrawal syndrome induced by morphine and naloxone.
Chemische Eigenschaften
White Powder
Verwenden
Otilonium bromide is an antimuscarinic
Allgemeine Beschreibung
Otilonium bromide is an antispasmodic. It contains a red color ACh (acetylcholine) like moiety bound to an aromatic system that ends with an octyl ether.
Sicherheitsprofil
Poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of Brí and NOx.
Otiloniumbromid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Otiloniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 216)Lieferanten
26095-59-0(Otiloniumbromid)Verwandte Suche:
- Menoctyl
- N,N-Diethyl-N-methy-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]ethanaminium Bromide
- Pasminox
- SP-63
- Spasen
- Spasmoctyl
- Spasmome
- OTYLONIUMBROMIDE
- diethyl-methyl-[2-[4-[(2-octoxybenzoyl)amino]benzoyl]oxyethyl]azanium bromide
- Aotixiuan
- OtioniuM BroMide
- OtiloniuM broMide(OctyloniuM broMide)
- Octylonium IodideDiscontinued See: O293250
- Ethanaminium, N,N-diethyl-N-methyl-2-[[4-[[2-(octyloxy)benzoyl]amino]benzoyl]oxy]-, bromide (1:1)
- ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,p-(o-(octyloxy)benzamido)ben
- diethyl(2-hydroxyethyl)methylammoniumbromidep-(o-(octyloxy)benzamido)benzoa
- ethanaminium,n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)
- octylonium
- ottiloniobromuro
- n,n-diethyl-n-methyl-2-((4-((2-(octyloxy)benzoyl)amino)benzoyl)oxy)-ethanaminium bromide
- OCTYLONIUM IODIDE
- otilonium bromide
- diethyl(2-hydroxyethyl) methylammonium bromide p-(o-(octyloxy)benzamido)-benzoate
- Doralin
- diethyl-[2-[[4-[[(2-heptoxyphenyl)-oxomethyl]amino]phenyl]-oxomethoxy]ethyl]-methylammonium bromide
- aoixijan
- DORALIN;OCTYLONIUM BROMIDE;SP63;SPASMOMEN
- Otilonium bromide USP/EP/BP
- Otilonium bromideQ: What is
Otilonium bromide Q: What is the CAS Number of
Otilonium bromide Q: What is the storage condition of
Otilonium bromide
- Otilonium
- Spasmomen
- OCTYLONIUM BROMIDE
- SPASMONEN
- Isoleucine Impurity 14
- 26095-59-0
- C29H43BrN2O4
- C29H43IN2O4
- C29H43N2O4Br
- BrC29H43N2O4
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
