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SB 223412

SB 223412 Struktur
174636-32-9
CAS-Nr.
174636-32-9
Englisch Name:
SB 223412
Synonyma:
CS-1123;SB 223412;Talnetant (SB 223412);SB-223412; SB223412; SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;(S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
CBNumber:
CB71333041
Summenformel:
C25H22N2O2
Molgewicht:
382.45
MOL-Datei:
174636-32-9.mol
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SB 223412 Eigenschaften

Schmelzpunkt:
125.1-126.2℃
Siedepunkt:
580.4±50.0 °C(Predicted)
Dichte
1.212±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
DMSO: soluble25mg/mL, clear
Aggregatzustand
powder
pka
6.70±0.50(Predicted)
Farbe
white to beige
Optische Aktivität
[α]/D -25 to -31°, c = 0.5 in methanol
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 25
S-Sätze: 45
RIDADR  UN 2811 6.1 / PGIII
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

SB 223412 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.

SB 223412 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Oxycinchophen (S)-(-)-1-Amino-1-phenylpropane

Downstream Produkte

SB 223412 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 78)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665
 dominicguo@gk-bio.com CHINA 9427 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8474 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203
 info@chemextension.com China 42057 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
  • SB 223412
  • 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
  • (-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide
  • TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide
  • (-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide
  • (S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide
  • 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide
  • 3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
  • SB-223412; SB223412; SB 223412
  • Talnetant (SB 223412)
  • CS-1123
  • Talnetant/(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
  • 4-Quinolinecarboxamide, 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-
  • (S)-3-Hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
  • schizophrenia,SB223412,NK receptor,Inhibitor,hNK-2,Talnetant,Neurokinin Receptor,Tachykinin receptor,NK3 receptor,SB-223412,inhibit
  • 174636-32-9
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