1-Ethylbenzimidazolin-2-on
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- CAS-Nr.
- 10045-45-1
- Bezeichnung:
- 1-Ethylbenzimidazolin-2-on
- Englisch Name:
- 1-EBIO
- Synonyma:
- EBIO;1-EB10;1-EBIO;Einecs 233-148-1;1-EthylbenziMidazolinone;1-ETHYL-2-BENZIMIDAZOLINONE;1-ethylbenzimidazolin-2-one;1-ETHYL-2-BENZCMIDAZOLINONE;1-Ethyl-2-benzimidazolineone;3-ethyl-1H-benzimidazol-2-one
- CBNumber:
- CB7146587
- Summenformel:
- C9H10N2O
- Molgewicht:
- 162.19
- MOL-Datei:
- 10045-45-1.mol
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1-Ethylbenzimidazolin-2-on Eigenschaften
- Schmelzpunkt:
- 118-120 °C(Solv: ethyl acetate (141-78-6))
- Dichte
- 1.161±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- pka
- 12.29±0.30(Predicted)
- Farbe
- Crystalline
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
1-Ethylbenzimidazolin-2-on Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 μM in T84 human carcinoma cells).This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 μM).1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.
Verwenden
1-EBIO stimulates Cl- secretion in secretory epithelia through direct activation of clacium potassium channels.
1-EBIO was used to study the electrical activity modulated by Ca+2-activated K+ channels in rat central neurons. The effect of 1-EBIO on human intermediate conductance channels was studied.
The K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients
Biologische Aktivität
Activator of epithelial K Ca channels, stimulates a large and sustained trans-epithelial Cl - secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells.
1-Ethylbenzimidazolin-2-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-Ethylbenzimidazolin-2-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 106)Lieferanten
10045-45-1(1-Ethylbenzimidazolin-2-on)Verwandte Suche:
- 1-Ethyl-1H-benzimidazole-2(3H)-one
- 1-Ethyl-2,3-dihydro-1H-benzimidazole-2-one
- EBIO
- 1-Ethyl-2-benzimidazolinone,98%
- Einecs 233-148-1
- 1-EB10
- 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one(SALTDATA: FREE)
- 1-EBIO, 1-Ethyl-2-benzimidazolinone
- 1-Ethyl-1H-benzo[d]iMidazol-2(3H)-one
- 1-EthylbenziMidazolinone
- 1-ETHYL-2-BENZIMIDAZOLINONE
- 1-ETHYL-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
- 1-EBIO
- 1-Ethyl-2-benzimidazolineone
- 1-ethylbenzimidazolin-2-one
- 1-ETHYL-2-BENZCMIDAZOLINONE
- 2H-Benzimidazol-2-one,1-ethyl-1,3-dihydro-(9CI)
- 3-ethyl-1H-benzimidazol-2-one
- 2H-Benzimidazol-2-one, 1-ethyl-1,3-dihydro-
- 1-Ethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one
- 10045-45-1
- BENZIMIDAZOLE
- Potassium channel
- Ion Channels
