5-Hydroxy-2-hydroxymethyl-4-pyron
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- CAS-Nr.
- 501-30-4
- Bezeichnung:
- 5-Hydroxy-2-hydroxymethyl-4-pyron
- Englisch Name:
- Kojic acid
- Synonyma:
- kojic;kojic acid powder;KAD;5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE;4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-;5-Hydroxy-2-(hydroxyMethyl)-4H-pyranone;KJ ACID;NSC 1942;Kojic acid;Kojci Acid
- CBNumber:
- CB7272507
- Summenformel:
- C6H6O4
- Molgewicht:
- 142.11
- MOL-Datei:
- 501-30-4.mol
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5-Hydroxy-2-hydroxymethyl-4-pyron Eigenschaften
- Schmelzpunkt:
- 152-155 °C (lit.)
- Siedepunkt:
- 179.65°C (rough estimate)
- Dichte
- 1.1712 (rough estimate)
- Brechungsindex
- 1.4434 (estimate)
- storage temp.
- Store below +30°C.
- Löslichkeit
- DMSO (Slightly), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Crystalline Powder
- pka
- 7.9(at 25℃)
- Farbe
- White to beige-brown
- Wasserlöslichkeit
- SOLUBLE
- maximale Wellenlänge (λmax)
- 269nm(CHCl3)(lit.)
- Merck
- 14,5317
- BRN
- 120895
- Stabilität:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- LogP
- -0.640
- CAS Datenbank
- 501-30-4(CAS DataBase Reference)
- NIST chemische Informationen
- 5-Hydroxy-2-(hydroxymethyl)-4h-pyran-4-one(501-30-4)
- IARC
- 3 (Vol. 79) 2001
- EPA chemische Informationen
- Kojic acid (501-30-4)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P308+P313 |
BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P405 |
Unter Verschluss aufbewahren. |
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5-Hydroxy-2-hydroxymethyl-4-pyron Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R68:Irreversibler Schaden möglich.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
tan powder
Verwenden
kojic acid is a skin-lightening agent that acts through anti-oxidant activity. Kojic acid is a tyrosinase inhibitor, although it is not as effective as licorice extract. When combined with allantoin and other proper ingredients in sunscreen preparations, the mixture can inhibit uV-caused erythema and accelerate wound healing. It is also found to be skin sensitizing and can be irritating.
Definition
ChEBI: A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae.
Allgemeine Beschreibung
Kojic acid, a tyrosinase inhibitor, is produced by several fungi species, including
Aspergillus oryzae. It exhibits skin-lightening property, due to its ability to chelate the copper-containing enzyme tyrosinase in the formation of melanin. Kojic acid is also commonly used as a whitening agent in regular cosmetics, bleaching cosmetics, etc. It is found to be a therapeutic agent and helps in preventing pigmentation.
läuterung methode
Crystallise the acid from MeOH (charcoal) by adding Et2O. It sublimes at 150-200o/0.1torr. [Beilstein 18 II 57, 18 III/IV 1145, 18/2 V 516.]
5-Hydroxy-2-hydroxymethyl-4-pyron Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Hydroxy-2-methyl-4-pyron
2-Ethyl-3-hydroxy-4H-pyran-4-on
5-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid
4H-Pyran-4-one,3-methoxy-(6CI,7CI,8CI,9CI)
2-amino-4-(2-fluorophenyl)-6-(hydroxymethyl)-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile
3-(benzyloxy)-1,4-dihydropyridin-4-one
4-Thiazoleacetic acid, α-[[[1,5-bis(diphenylmethoxy)-1,4-dihydro-4-oxo-2-pyridinyl]methoxy]imino]-2-[(triphenylmethyl)amino]-, (αZ)-
2,3-DIHYDRO[1,4]DIOXINO[2,3-C]PYRIDINE-7-CARBALDEHYDE
WS 75624 B
5-Hydroxy-2-hydroxymethyl-4-pyron Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 711)Lieferanten
501-30-4(5-Hydroxy-2-hydroxymethyl-4-pyron)Verwandte Suche:
- 4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl)-
- 5-hydroxy-2-(hydroxymethyl)-4h-pyran-4-on
- Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)
- 2-HYDROXYMETHYL-5-HYDROXY-4-PYRONE
- 5-Hydroxy-2-(hydroxymethyl)-γ-pyrone
- Kojic acid
- Kojic acid 99%
- NSC 1942
- Kojic Acid Solution
- Kojic acid, 99% 5GR
- Kojic acid, 98%+
- 5-Hydroxy-2-(hydroxymethyl)
- 5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one for synthesis
- 2-HYDROXYMETHYL-5-HYDROXY-GAMMA-PYRONE
- 2-HYDROXYMETHYL-5-HYDROXY-1,4-PYRONE
- 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one
- KNUDSON C ORCHID MEDIUM
- 2-Hydroxymethyl-5-hydroxy-γ-pyrone, 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
- 2-(Hydroxymethyl)-5-hydroxy-4H-pyran-4-one
- 5-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one Solution
- 4-Oxo-5-hydroxy-4H-pyran-2-methanol
- Kojic Acid (5-Hydroxy-2-hydroxymethyl-4-pyrone)
- 5-HYDROXY-2-(HYDROXYMETHYL)-4-PYRONE
- 5-HYDROXY-2-HYDROXYMETHYL-PYRAN-4-ONE
- 5'-HYDROXY-2-(HYDROXYMETHYL)-1,4-PYRANONE
- 5-HYDROXY-2-HYDROXYMETHYL-4H-4-PYRANONE
- 5-HYDROXY-2-HYDROXYMETHYL-4-PYRANONE
- LABOTEST-BB LT00068503
- KJ ACID
- TIMTEC-BB SBB005397
- Kojic acid(whitening agent in cosmetic)
- KOJIC ACID CRYSTALLINE
- KOJIC ACID SOLUTION [FOR SPRAY]
- Kojci Acid
- Kojicacid,99%
- 2-hydroxymethyl-5-hydroxy-γ-pyrone
- KOJICACID(BULK
- KOJIC ACID(RG)
- Nano Liposomal Kojicacid
- Kojic acid2-Hydroxymethyl-5-hydroxy-γ-pyrone 5-Hydroxy-2-hydroxymethyl-4H-4-pyranone
- KojicAcid>
- skin whitening effect kojic acid
- Kojic Impurity 1
- High Quality Skin whitening organic acide kojic
- Kojic acid ISO 9001：2015 REACH
- CAS 501-30-4 Skin Whitening 99% Kojic Acid Powder
- aKojic acid
- Kojic acid extrapure, 99%
- 4H-Pyran-4-one, 5-hydroxy-2-(hydroxymethyl)-
- kojic
- 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE
- kojic acid powder
- KAD
- 5-Hydroxy-2-(hydroxyMethyl)-4H-pyranone
- Iridium(III) chloride hydrate 14996-61-3
- acid powder
- 501-30-4
- Tyrosinase inhibitor.
