Loxoribine
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- CAS-Nr.
- 121288-39-9
- Englisch Name:
- Loxoribine
- Synonyma:
- RWJ 21757;Loxoribine;7,8-Dihydro-8-oxo-7-allyl-guanosine;7-Allyl-7,8-dihydro-8-oxoguanosine 95%;7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95;7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-;7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-;7-Allyl-7,8-dihydro-8-oxoguanosine
(Loxoribine)
- CBNumber:
- CB7499469
- Summenformel:
- C13H17N5O6
- Molgewicht:
- 339.3
- MOL-Datei:
- 121288-39-9.mol
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Loxoribine Eigenschaften
- Schmelzpunkt:
- 227-230 °C(lit.)
- Dichte
- 1.92±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- Löslichkeit
- Soluble in DMSO (up to 25 mg/ml).
- Aggregatzustand
- White to off-white solid.
- pka
- 10.29±0.20(Predicted)
- Farbe
- White
- Optische Aktivität
- [α]21/D 32°, c = 1 in H2O
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
29349990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Loxoribine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7). It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC
50s = 10-50, 3-20, and 13-22 μM, respectively). Loxoribine (250 μM) increases production of IL-12, IL-23, IL-27, and IL-10 by human monocyte-derived dendritic cells (MoDCs). Loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4
+ T cells compared to control MoDCs. Loxoribine (120 mg/kg) reduces the number of pulmonary metastases in the B16 mouse model of melanoma, an effect enhanced by co-administration of IL-2, and exhibits adjuvant activity in mice immunized with a B16 tumor vaccine.
Chemische Eigenschaften
White Solid
Verwenden
Small-molecule immunostimulants
Biologische Aktivität
Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
Loxoribine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Loxoribine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 77)Lieferanten
121288-39-9()Verwandte Suche:
- 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95
- Loxoribine
- 7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione
- 7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine
- RWJ 21757
- Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-
- 7-Allyl-7,8-dihydro-8-oxoguanosine 95%
- 7,8-Dihydro-8-oxo-7-allyl-guanosine
- 7-Allyl-7,8-dihydro-8-oxoguanosine
(Loxoribine)
- Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-
- 7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine
- 7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95 USP/EP/BP
- RWJ-21757,Loxoribine,natural,Toll-like Receptor (TLR),killer,cells,Influenza Virus,Inhibitor,cells,inhibit,TLR-7,MoDCs,RWJ21757
- 121288-39-9
- Heterocyclic Compounds
- Bases & Related Reagents
- Heterocycles
- Nucleotides
- Nucleosides
- Oligonucleotide Synthesis
- Specialty Synthesis
