Ivabradine hydrochloride
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- CAS-Nr.
- 148849-67-6
- Englisch Name:
- Ivabradine hydrochloride
- Synonyma:
- Ivabradine HCl;Procoralan;Ivabradine hydrochlorid;CS-774;S-16257;Corlentor;S 16257-2;2H-3-Benzazepin-2-on;Ivabridine hydracloride;Ivabradine hydrochloride
- CBNumber:
- CB81006694
- Summenformel:
- C27H37ClN2O5
- Molgewicht:
- 505.05
- MOL-Datei:
- 148849-67-6.mol
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Ivabradine hydrochloride Eigenschaften
- Schmelzpunkt:
- 193-196?C
- alpha
- 58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
- storage temp.
- 2-8°C
- Löslichkeit
- H2O: ≥5mg/mL (warmed)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivität
- [α]/D +5 to +9°, c = 1 in DMSO
- Merck
- 14,5247
- InChIKey
- HLUKNZUABFFNQS-ZMBIFBSDSA-N
- SMILES
- C([C@H]1CC2=CC(OC)=C(OC)C=C12)N(C)CCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r|
- CAS Datenbank
- 148849-67-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
N |
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| R-Sätze: |
50/53 |
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| S-Sätze: |
60-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
2933.79.1500 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gewässergefährdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Ivabradine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
In an effort to develop angina agents without the unwanted negative
inotropic and hypotensive effects associated with b-adrenergic blockers and
calcium channel blockers, a new class of heart-rate reducing compounds that act
specifically on the sinoatrial (SA) node has been explored. These bradycardic
agents interact directly with the pacemaking cell of the SA node and the hyperpolarization-
activated If , the primary pacemaking current. Ivabradine has
evolved as a specific inhibitor of If current through its contact with f-channels on
the intracellular side of the plasma membrane. As a consequence, ivabradine
reduces the speed of diastolic depolarization and decreases heart rate. It has been
approved for the treatment of chronic stable angina and provides a viable
alternative to patients with a contraindication or intolerance of b-blockers. Evaluation
is also underway for the potential treatment of ischemic heart disease.
Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If
current ranged from 6% (0.03 mM) – 80% (10 mM).
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Chemische Eigenschaften
White to Off-White Solid
Verwenden
Ivabradine hydrochloride has been used as a potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel (HCN)2 blocker in embryoid body (EB) and rat engineered heart tissue (EHT).
Definition
ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydrochloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.
Ivabradine hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one hydrochloride
3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3-dihydro-7,8-diMethoxy-H-3-benzazepin-2-one
(1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride
Downstream Produkte
Ivabradine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 454)Lieferanten
148849-67-6()Verwandte Suche:
- Ivabradine hydrochloride
- 3-[3-[[(8S)-3,4-Dimethoxy-8-bicyclo[4.2.0]octa-1,3,5-trienyl]methyl-methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one hydrochloride
- Ivabradine hydrochloride, >=99%
- IVABRADINE HYDROCHLORIDE-OTHER COMPOUNDSCONTAINING AN UNFUSED PYRAZOLE RING(WHETHER OR NOT HYDROGENATED)IN THE STRUCTUR
- 3-[3-[[[(7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one Hydrochloride
- Corlentor
- S-16257
- (7,8-Dimethoxy 3-(3-(((1S)-(4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one hydrochloride
- 2H-3-Benzazepin-2-one, 3-(3-((((7S)-3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride
- 2H-3-Benzazepin-2-one, 3-(3-(((3,4-dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-, monohydrochloride, (S)-
- Ivabridine hydracloride
- 2H-3-Benzazepin-2-one,3-[3-[[[(7S)-3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-,hydrochloride (1:1)
- 3-[3-[[(3,4-diMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl]MethylaMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-, Monohydrochloride
- 2H-3-Benzazepin-2-on
- Ivabradine HCl (Procoralan)
- (S)-3-(3-(((3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)Methyl)(Methyl)aMino)propyl)-7,8-diMethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride
- S 16257-2
- 3-[3-[[[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl]methylamino]propyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one,hydrochloride (1:1)
- Ivabradine hydrochloride, 98%, a If inhibitor
- lvabradine hydrochloride
- CS-774
- IvabradineHydrochloride>
- Ivabradine hydrochloride USP/EP/BP
- Ivabradine Hydrochloride Impurities
- (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
- Ivabradine HydrochlorideQ: What is
Ivabradine Hydrochloride Q: What is the CAS Number of
Ivabradine Hydrochloride Q: What is the storage condition of
Ivabradine Hydrochloride Q: What are the applications of
Ivabradine Hydrochloride
- Ivabradine HCl
- Procoralan
- Ivabradine hydrochlorid
- 2-Propen-1-one,1-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyphenyl)-,(6E)-
- (S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride
- 148849-67-6
- Ivabradine Hydrochloride
(S)-3-(3-(((4,5-dimethoxy-1,2 dihydrocyclobutabenzen1yl)methyl)(methyl)amino)propyl)-7,8- dimethoxy-4,5-dihydro-1Hbenzo[d]azepin-2(3H)-one hydrochloride
- 148849-67-6
- 148849-54-6
- 48849-67-6
- 1448849-67-6
- C27H37ClN2O5
- C27H36N2O5HCl
- Chiral Reagents
- Heterocycles
- API
- Cardiovascular APIs
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Inhibitors
