4-Chlorresorcin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
4-Chlororesorcinol is a colorless crystals or off-white to light brown powder. The melting point is 89°C (106.5-107.5°C), the boiling point is 259°C, 147°C (2.4kPa). Soluble in water, alcohol, ether, benzene and carbon disulfide. Can sublimate. It reacts with ferric chloride to generate blue-purple.
Verwenden
4-Chlororesorcinol, can be used as hair dye formulation. It can also be used in the synthesis of series of six coumarin compounds carrying halogen and trifluoromethyl, having antifungal activities.
Application
In cosmetics and personal care products, 4-Chlororesorcinol is used in the formulation of hair dyes, colors and tints.
4-Chlororesorcinol is used in permanent hair coloring systems where color is produced inside the hair fiber. This is accomplished through careful formulation of the product so that the ingredients interact in a highly controlled process.
synthetische
4-Chlororesorcinol is synthesized by reacting resorcinol with dichlorosulfuryl. Resorcinol and diethyl ether were mixed, heated to reflux with stirring, and dichlorosulfuryl was slowly added dropwise. The temperature was then raised to 60°C for 1 h. After recovery of ether, atmospheric distillation is carried out, the distillate is subjected to vacuum distillation again, and the 131°C (0.8-0.93kPa) or 160-164°C (4.0kPa) fractions are collected to obtain the finished 4-chlororesorcinol.
Sicherheit(Safety)
4-chlororesorcinol is classified as a toxic substance and exposure to high concentration of 4-chlororesorcinol could cause several health issues including, skin irritation, serious eye irritation, and other hazards.
The safety of 4-Chlororesorcinol has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that 4-Chlororesorcinol was safe in hair dye formulations.
The CIR Expert Panel concluded that the scientific data suggested that 4-Chlororesorcinol can be safely used in hair dye products. Subchronic dermal exposure to a hair dye product containing 2% 4-Chlororesorcinol produced no evidence of compound-induced toxicity. At the same concentration, no development effects, no evidence of reproductive toxicity, and no carcinogenic effects were seen following dermal exposure. Likewise, 4-Chlororesorcinol was not mutagenic in either a micronucleus or in bacteria, nor did it induce aneuploidy in fungus cells. A 2.5% solution was not a dermal irritant or an ocular irritant.
läuterung methode
Crystallise it from boiling CCl4 (10g/L, charcoal) and dry it in air. [Beilstein 6 II 818.] IRRITANT.
4-Chlorresorcin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
