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Norethisterone

CAS No.
68-22-4
Chemical Name:
Norethisterone
Synonyms
Elk;ENT;NET;Cek6;Elkh;Hek6;EPB1;EPHB1;EPHT2;EPTH2
CBNumber:
CB00125983
Molecular Formula:
C20H26O2
Molecular Weight:
298.43
MDL Number:
MFCD00067596
MOL File:
68-22-4.mol
MSDS File:
SDS
Last updated:2023-12-22 14:15:20

Norethisterone Properties

Melting point 205-206 °C (lit.)
alpha D20 -31.7° (chloroform); D20 -25° (chloroform)
Boiling point 379.83°C (rough estimate)
Density 1.0766 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. 2-8°C
solubility chloroform: ≥50 mg/mL, clear, colorless
pka 13.09±0.40(Predicted)
form powder
color white to off-white
Water Solubility 7.043mg/L(25 ºC)
Merck 6697
BRN 1915671
BCS Class 1
InChIKey VIKNJXKGJWUCNN-XGXHKTLJSA-N
CAS DataBase Reference 68-22-4(CAS DataBase Reference)
FDA UNII T18F433X4S
Proposition 65 List Norethisterone (Norethindrone)
NCI Drug Dictionary Norlutate
ATC code G03AC01,G03DC02
NIST Chemistry Reference Norethindrone(68-22-4)
EPA Substance Registry System Norethisterone (68-22-4)

Pharmacokinetic data

Protein binding 60%
Excreted unchanged in urine 50-80 (as metabolites)
Volume of distribution 3.1-5.7(L/kg)
Biological half-life 5 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS08,GHS09
Signal word  Danger
Hazard statements  H351-H360FD-H362-H410
Precautionary statements  P202-P260-P263-P264-P273-P308+P313
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  22-36/37/39-45-37/39-26
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  RC8975000
HS Code  29144000
Toxicity LD50 oral in mouse: 6gm/kg
NFPA 704
0
3 0

Norethisterone price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB4500732 Anti-EPHB1 antibody produced in rabbit affinity isolated antibody 68-22-4 100μG $506 2024-03-01 Buy
Sigma-Aldrich N4128 19-Norethindrone ≥98%, powder 68-22-4 1g $70.4 2024-03-01 Buy
Sigma-Aldrich BP266 Norethisterone British Pharmacopoeia (BP) Reference Standard 68-22-4 50MG $223 2024-03-01 Buy
Sigma-Aldrich 1469005 Norethindrone United States Pharmacopeia (USP) Reference Standard 68-22-4 200mg $436 2024-03-01 Buy
Cayman Chemical 20941 Norethindrone ≥98% 68-22-4 250mg $32 2024-03-01 Buy
Product number Packaging Price Buy
SAB4500732 100μG $506 Buy
N4128 1g $70.4 Buy
BP266 50MG $223 Buy
1469005 200mg $436 Buy
20941 250mg $32 Buy

Norethisterone Chemical Properties,Uses,Production

Uses

Norethindrone is used to treat endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms). Norethindrone is also used to treat abnormal periods or bleeding and to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 3 months and who are not pregnant or experiencing menopause (change of life; the end of monthly menstrual periods). Norethindrone is in a class of medications called progestins. It works by stopping the lining of the uterus from growing and by causing the uterus to produce certain hormones. Norethindrone is also used to prevent pregnancy.

Side effects

Some side effects of Norethindrone can be serious, though uncommon. If you experience any of the following symptoms, it's important to contact your doctor immediately: loss of vision, blurred vision, double vision, bulging eyes, migraine headache, pain, warmth, or heaviness in the back of the lower leg, shortness of breath, coughing up blood, sudden sharp or crushing chest pain, heaviness in chest, slow or difficult speech, dizziness or faintness, weakness or numbness of an arm or leg, swelling of the arms, hands, feet, ankles, or lower legs, yellowing of the skin or eyes, depression, mood swings, missed periods, sudden, severe pain in the abdomen (area between the chest and waist), hives, rash, itching, difficulty breathing, or swallowing. Additionally, Norethindrone may cause other side effects not listed here, so it's essential to reach out to your doctor if you experience any unusual problems while taking this medication.

storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.

Dosage

Norethindrone comes as a tablet to take by mouth. Norethindrone is taken on different schedules that depend on the condition that is being treated and on how well norethindrone works to treat the conditions. When norethindrone is used to treat endometriosis, it is usually taken once a day for 6 to 9 months or until breakthrough bleeding becomes bothersome. When norethindrone is used to bring on a normal cycle in women who have stopped menstruating, it is usually taken once a day for 5 to 10 days during the second half of the planned menstrual cycle. To help you remember to take norethindrone, take it at around the same time of day every day that you are scheduled to take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take norethindrone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are taking norethindrone for endometriosis, your doctor will probably start you on a low dose of norethindrone and gradually increase your dose, not more than once every 2 weeks.
Norethindrone may control your condition but will not cure it. Continue to take norethindrone even if you feel well. Do not stop taking norethindrone without talking to your doctor.

734-32-7
74-86-2
68-22-4
Synthesis of Norethisterone from Norandrostenedione and Acetylene
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View Lastest Price from Norethisterone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
norethisterone pictures 2023-09-19 norethisterone
68-22-4
US $40.00-40.00 / kg 1kg 0.99 10 tons Hebei Yanxi Chemical Co., Ltd.
norethisterone pictures 2021-03-17 norethisterone
68-22-4
US $0.00 / ASSAYS 1ASSAYS 99.9% 1 ton Hebei shuoxi biotechnology co. LTD
norethisterone pictures 2018-10-22 norethisterone
68-22-4
US $10.00 / KG 10G 99% 1000kg Meihua Biological Technology Co.,Ltd
  • norethisterone pictures
  • norethisterone
    68-22-4
  • US $40.00-40.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • norethisterone pictures
  • norethisterone
    68-22-4
  • US $0.00 / ASSAYS
  • 99.9%
  • Hebei shuoxi biotechnology co. LTD
  • norethisterone pictures
  • norethisterone
    68-22-4
  • US $10.00 / KG
  • 99%
  • Meihua Biological Technology Co.,Ltd
17a-ethynyl-19-nortestosterone 17ALPHA-ETHYNYL-17BETA-HYDROXY-19-NOR-4-ANDROSTEN-3-ONE 17ALPHA-ETHYNYL-19-NORTESTOSTERONE 19-NOR-4-ANDROSTEN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE 19-NOR-4-ETHISTERONE 19-NORETHINDRONE 19-NORETHISTERONE 19-NOR-17ALPHA-ETHYNYL-4-ANDROSTEN-17BETA-OL-3-ONE 19-NOR-17ALPHA-ETHYNYLTESTOSTERONE NORLUTIN NORETHISTERONE NORETHINDRONE (17-alpha)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one (17alpha)-19-norpregn-4-en-20-yn-3-on 17-alpha-19-Norpregn-4-en-20-yn-3-one, 17-hydroxy- 17-alpha-ethinyl-17-beta-hydroxy-delta(sup:4)-estren-3-one 17alpha-Ethinyl-17beta-hydroxy-delta(sup:4)-estren-3-one 17-alpha-ethinyl-19-nortestosterone 17alpha-Ethinyl-19-Nortestosterone 17-alpha-ethinylestra-4-en-17-beta-ol-3-one (17α)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one 19-Nor-17α -ethynyl-4-androsten-17β-ol-3-one 17alpha-Ethynyl-19-nortestosterone 19-Nor-17alpha-ethynyltestosterone 17-hydroxy-(8α,17βH)-19-nor-pregn-4-en-20-yn-3-one (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-Methyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one EPHB1 Cek6 9330129L11 AW488255 Elk Elkh EPHB1 (591-end), active, GST tagged from mouse EPHT2 Hek6 Anti-EPHB1 antibody produced in rabbit Norethindrone, USP 19-Norpregn-4-en-20-yn-3-one,17-hydroxy-, (17a)- 19-Norpregn-4-en-20-yn-3-one, 17-hydroxy-, (17α)- Norethindrone Solution, 100ppm (8R,9S,10R,13S,14S,17R)-17-ETHYNYL-17-HYDROXY-13-METHYL-1,2,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE 4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE 17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE 17-hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one 17alpha-Ethinylestra-4-en-17beta-ol-3-one 17-alpha-ethynyl-17-beta-hydroxy-19-norandrost-4-en-3-one 17alpha-Ethynyl-17beta-hydroxy-19-norandrost-4-en-3-one 17-alpha-Ethynyl-17-beta-hydroxy-4-estren-3-one 17-alpha-ethynyl-17-beta-hydroxyestr-4-en-3-one 17alpha-Ethynyl-17beta-hydroxyestr-4-en-3-one 17-alpha-ethynyl-17-hydroxy-4-estren-3-one 17-Hydroxy-17-alpha-19-norpregn-4-en-20-yn-3-one 17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-on 17-hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-on 17-hydroxy-19-nor-17-alpha-pregn-4-en-20-yn-3-one 17-Hydroxy-19-nor-17alpha-pregn-4-en-20-yn-3-one 19-nor-17alpa-ethynyltestosterone 19-nor-17-alpha-ethynyl-17-beta-hydroxy-4-androsten-3-one 19-nor-17alpha-Ethynyl-17beta-hydroxy-4-androsten-3-one