ChemicalBook >> CAS DataBase List >>Simethicone
Simethicone
- CAS No.
- 9016-00-6
- Chemical Name:
- Simethicone
- Synonyms
- Simethicone;Dimethylpolysiloxane;SILICONE FLUID;POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERM;baros;silain;Dimethylpolysiloxan;Simethicone Emulsion 30%;dimethyl(l1-oxidaneyl)-l3-silane;POLYDIMETHYLSILOXANES, TRIMETHYLSILOXY TERMINATED
- CBNumber:
- CB00127866
- Molecular Formula:
- C5H6Si
- Molecular Weight:
- 94.18664
- MDL Number:
- MFCD00148360
- MOL File:
- 9016-00-6.mol
Last updated:2024-05-07 17:43:10
| Melting point | -35°C |
|---|---|
| Boiling point | 155-220°C |
| Density | 0.971 |
| vapor pressure | 5 mm Hg ( 20 °C) |
| refractive index | 1.4035 |
| Flash point | 63°C |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Viscous Liquid |
| Specific Gravity | 0.918 |
| color | Colorless |
| Water Solubility | INSOLUBLE |
| Stability | Stable. Flammable or combustible. Flammability depends upon extent of polymerization. Incompatible with strong oxidizing agents. |
| Substances Added to Food (formerly EAFUS) | DIMETHYLPOLYSILOXANE |
| FDA 21 CFR | 175.105; 176.200; 177.2800; 178.3910; 310.545 |
| EWG's Food Scores | 1 |
| NCI Drug Dictionary | simethicone |
| EPA Substance Registry System | Poly[oxy(dimethylsilylene)] (9016-00-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H227 | |||||||||
| Precautionary statements | P210e-P370+P378a-P403+P235-P210-P240-P241-P280a-P303+P361+P353-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TQ2690000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| HS Code | 39100000 | |||||||||
| NFPA 704 |
|
Simethicone price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1546300 | Polydimethylsiloxane United States Pharmacopeia (USP) Reference Standard | 9016-00-6 | 500mg | $491 | 2024-03-01 | Buy |
| Alfa Aesar | 042490 | Polydimethylsiloxane, trimethylsiloxy terminated, M.W. 14,000 | 9016-00-6 | 50ml | $22.65 | 2024-03-01 | Buy |
| Alfa Aesar | 042490 | Polydimethylsiloxane, trimethylsiloxy terminated, M.W. 14,000 | 9016-00-6 | 1L | $124.65 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1518 | Polydimethylsiloxane Pharmaceutical Secondary Standard; Certified Reference Material | 9016-00-6 | 1g | $103 | 2024-03-01 | Buy |
| Sigma-Aldrich | DMPSV | Dimethylpolysiloxane viscosity 5 cSt (25 °C)(lit.) | 9016-00-6 | 500g | $162 | 2024-03-01 | Buy |
Simethicone Chemical Properties,Uses,Production
General Description
Simethicone, a silicone compound, is utilized for alleviating flatulence and bloating, ameliorating the discomfort arising from excessive gas accumulation in the gastrointestinal tract. Its efficacy was confirmed by FDA approval in 1952. Over the years, research has explored its potential as a skin protectant and in the treatment of Helicobacter pylori.
Pharmaceutical Applications
Simethicone has garnered attention among endurance athletes for its potential in mitigating exercise-induced GI symptoms. Despite investigations into its efficacy for infantile colic, no significant benefits were found. Notably, simethicone is not indicated for conditions such as ileus, small bowel obstruction, or constipation. Careful consideration of alternative causes, including gallstones or heart disease, is prudent when employing simethicone.
Furthermore, manifestations like vomiting, hematochezia, and severe abdominal tenderness warrant thorough examination. Simethicone has also demonstrated safety and tolerability as part of a contrast agent, enhancing sonographic imaging in abdominal diagnostics.
Side effects
There is no report about serious side effects caused by Simethicone. There have been reports of mild diarrhea and nausea. Since simethicone is not absorbed orally, it is logical that systemic side effects such as kidney injury, hypertension, and hyperglycemia do not occur. Silicosis is a condition of pulmonary fibrosis caused by the inhalation of silica dust (also known as silicon dioxide). Still, there have been no reported cases of silicosis secondary to oral simethicone administration.
Safety
Simethicone is not absorbed systemically, so it is safe in pregnancy and breastfeeding. There is no treatment for a simethicone overdose other than stopping the medication.
Simethicone Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 288)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12470 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 19368 | 58 |
| Hangzhou Bayee Chemical Co., Ltd. | 0086-571-86990109 | rachelhoo@bayeechem.com | China | 104 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9340 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
View Lastest Price from Simethicone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-26 | Simethicone
8050-81-5
|
US $150.00 / ASSAYS | 10g | >99% | 500kg/month | Hebei Mingeng Biotechnology Co., Ltd | |
 |
2019-07-31 | Simethicone
9006-65-9
|
US $1.00 / g | 1g | 99% | 2000 Metric | Cangzhou Wanyou New Material Technology Co.,Ltd |
-
- Simethicone
8050-81-5
- US $150.00 / ASSAYS
- >99%
- Hebei Mingeng Biotechnology Co., Ltd
-
- Simethicone
9006-65-9
- US $1.00 / g
- 99%
- Cangzhou Wanyou New Material Technology Co.,Ltd
9016-00-6(Simethicone)Related Search:
HEXAETHYLDISILOXANE
Octamethylcyclotetrasiloxane
Sodium tripolyphosphate
Poly(dimethylsiloxane)
1,1,3,3-Tetramethyldisiloxane
Hexamethyldisiloxane
Emulsified silicone oil
POLYDIETHYLSILOXANE, TRIETHYLSILOXY TERMINATED
POLY(DIMETHYLSILOXANE), METHYL TERMINATED
Dimethicone
1of4
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, BLEND
SILICONE FLUID, 100
SILICONE FLUID 1,000
SILICONE FLUID 500
Polydimethylsiloxane,trimethylsiloxyterminated,M.W.1250
Polydimethylsiloxane,trimethylsiloxyterminated,M.W.14,000
Polydimethylsiloxane,trimethylsiloxyterminated,M.W.2000
Polydimethylsiloxane,trimethylsiloxyterminated,M.W.28,000
Polydimethylsiloxane,trimethylsiloxyterminated,M.W.410
Poly(dimethylsiloxane), sec. standard, M.W. 90,200, M.N. 46,000
polydimethylsiloxane, trimethylsiloxy terminated, m.w. 139,000
polydimethylsiloxane, trimethylsiloxy terminated, m.w. 4000
polydimethylsiloxane, trimethylsiloxy terminated, m.w. 6000
polydimethylsiloxane, trimethylsiloxy terminated, m.w. 9000
polydimethylsiloxane, trimethylsiloxy terminated, m.w. 17,000
polydimethylsiloxane, trimethylsiloxy terminated, m.w. 237
ORGANO-POLYSILOXANES
POLYDIMETHYLSILOXANEFLUID
SILICONEEMULSIONY-12386
SILICONEOIL20CP
POLYDIMETHYLSILOXANE GUM, VISCOSITY 10-20.000.000 CST.
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED: VISCOSITY 1.5 CST.
RED DYE IN SILICONE, VISCOSITY 100 CST.
POLYDIMETHYLSILOXANE, EXTREME LOW VOLATILITY, VISCOSITY 1000 CST.
POLYDIMETHYLSILOXANE, REDUCED VOLATILITY, VISCOSITY 100 CST.
BLUE DYE IN SILICONE, VISCOSITY 100 CST.
POLYDIMETHYLSILOXANE SILICONE EMULSION, VISCOSITY >100000 CST.
POLYDIMETHYLSILOXANE, REDUCED VOLATILITY, VISCOSITY 20 CST.
POLYDIMETHYLSILOXANE, EXTREME LOW VOLATILITY, VISCOSITY 350 CST.
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, EXTREME LOW VOLATILITY, VISCOSITY 12.500 CST.
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, FLUID BLEND, VISCOSITY 200 CST.
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, REDUCED VOLATILITY, VISCOSITY 7.0 CST.
POLYDIMETHYLSILOXANE SILICONE EMULSION, VISCOSITY 1000 CST.
POLYDIMETHYLSILOXANE SILICONE EMULSION: 50% IN WATER, 10.000 CST.
POLYDIMETHYLSILOXANE SILICONE EMULSION: VISCOSITY 100 CST.
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, 5cs
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, 60,000cs
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, 600,000cs
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, 7cs
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, BLEND, 200-500cs
POLYDIMETHYLSILOXANE, TRIMETHYLSILOXY TERMINATED, COLORED
POLYDIMETHYLSILOXANE 1'850 FOR GPC
POLYDIMETHYLSILOXANE 25'800, FOR GPC
POLYDIMETHYLSILOXANE 197'000, FOR
POLYDIMETHYLSILOXANE 3'320 FOR GPC
POLYDIMETHYLSILOXANE 7'100, FOR GPC
POLYDIMETHYLSILOXANE 311, FOR GPC
POLYDIMETHYLSILOXANE 71'000 FOR GPC
POLYDIMETHYLSILOXANE 16'000, FOR GPC
POLYDIMETHYLSILOXANE 53'500 FOR GPC
POLYDIMETHYLSILOXANE 89'800, FOR GPC
POLYDIMETHYLSILOXANE 303'000 FOR &
POLYDIMETHYLSILOXANE 4'400 FOR GPC
POLYDIMETHYLSILOXANE 173'000, FOR GPC
DIMETHYLPOLYSILOXANE VISCOSITY*60,000 CE NTISTOKES
POLYDIMETHYLSILOXANE 47'500 FOR GPC
POLY(DIMETHYLSILOXANE), SECONDARY STANDA RD
SiliconeEmulsion(ForVialCoating)