Acid Folic

Acid Folic Properties

Melting point	250 °C
alpha	20 º (c=1, 0.1N NaOH)
Boiling point	552.35°C (rough estimate)
Density	1.4704 (rough estimate)
refractive index	1.6800 (estimate)
storage temp.	2-8°C
solubility	boiling water: soluble1%
form	Crystalline Powder
pka	pKa 2.5 (Uncertain)
color	Yellow to orange
Odor	Odorless
PH Range	4
Water Solubility	1.6 mg/L (25 ºC)
Merck	14,4221
BRN	100781
BCS Class	3
Stability	Stable. Incompatible with heavy metal ions, strong oxidizing agents, strong reducing agents. Solutions may be light and heat sensitive.
InChIKey	OVBPIULPVIDEAO-LBPRGKRZSA-N
LogP	-0.990 (est)
FDA 21 CFR	172.345; 102.23; 104.20; 310.545
Substances Added to Food (formerly EAFUS)	FOLIC ACID
CAS DataBase Reference	59-30-3(CAS DataBase Reference)
EWG's Food Scores	1
NCI Dictionary of Cancer Terms	folate; folic acid
FDA UNII	935E97BOY8
NIST Chemistry Reference	Folic acid(59-30-3)
NCI Drug Dictionary	folic acid
ATC code	B03BB01,B03BB51,V04CX02
EPA Substance Registry System	L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (59-30-3)

Pharmacokinetic data

Protein binding	70%
Excreted unchanged in urine	Varies with daily dose
Biological half-life	2.5 / -

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Risk Statements	33-62-68
Safety Statements	24/25
WGK Germany	1
RTECS	LP5425000
F	8
TSCA	Yes
HS Code	29362900
Toxicity	A water soluble vitamin required in the diet of mammals. Sulfonamide drugs are selectively toxic to bacteria because they inhibit the incorporation of p-aminobenzoic acid into folic acid, a biosynthetic process in bacteria. Folic acid deficiency adversely affects prenatal development in humans. Dietary supplementation with folic acid dramatically reduces the incidence of neural tube defects in humans. Folic acid deficiency may also contribute to the causes of megaloblastic macrocytic anemia and a consequence of this is that this disease can be induced, as a side effect, when methotrexate, a folic acid antagonist, is used in cancer chemotherapy

Acid Folic price More Price(55)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	F7876	Folic acid ≥97%	59-30-3	1g	$23.2	2024-03-01	Buy
Sigma-Aldrich	1286005	Folic acid United States Pharmacopeia (USP) Reference Standard	59-30-3	500mg	$447	2024-03-01	Buy
Sigma-Aldrich	BP937	Folic acid British Pharmacopoeia (BP) Reference Standard	59-30-3	150MG	$266	2023-06-20	Buy
TCI Chemical	F0043	Folic Acid Hydrate >98.0%(HPLC)(T)	59-30-3	25g	$65	2024-03-01	Buy
Alfa Aesar	J60833	Folic acid, crystalline	59-30-3	25g	$80.2	2024-03-01	Buy

Product number	Packaging	Price	Buy
F7876	1g	$23.2	Buy
1286005	500mg	$447	Buy
BP937	150MG	$266	Buy
F0043	25g	$65	Buy
J60833	25g	$80.2	Buy

Acid Folic Chemical Properties,Uses,Production

Description

Acid Folic is an essential B vitamin. It is converted to folate in vivo, which is a necessary cofactor for a variety of biological processes, including nucleotide synthesis and, thus, DNA synthesis and repair, among others. A deficiency in dietary acid folic can lead to a range of developmental and cognitive disorders, most prominently neural tube defects and congenital heart defects.

Chemical Properties

Acid solutions of Acid Folic are sensitive to heat, but towards neutrality, stability progressively increases. Solutions are inactivated by ultraviolet light and alkaline solutions are sensitive to oxidation. Acid Folic is also inactivated by light. It is incompatible with oxidizing agents, reducing agents and heavy metal ions.

Uses

Acid folic is generally used as an emollient. In vitro and in vivo skin studies now indicate its capacity to aid in DnA synthesis and repair, promote cellular turnover, reduce wrinkles, and promote skin firmness. There is some indication that acid folic may also protect DnA from uV-induced damage. Acid folic is a member of the vitamin B complex and is naturally occurring in leafy greens.

Side effects

The symptoms of a drug allergy include one or more of the following:

Swollen face/eyes/lips/tongue

Difficulty in breathing

Itchy skin rashes over your whole body

Physiological effects

Acid Folic is a type of vitamin naturally found in some foods that helps the body to produce red blood cells. A lack of folic acid may result in folate-deficiency anemia, a condition in which there is insufficient healthy red blood cells to provide oxygen to the body.

Acid Folic deficiency

Some symptoms of folate deficiency include:Trusted Source

weakness

fatigue

trouble concentrating

headache

irritability

heart palpitations

sores on the tongue and inside the mouth

a change in color of the skin, hair, or fingernails

irritability, headache, heart palpitations, and shortness of breath

Toxicity

Acid Folic is extremely rare to reach a toxic level when eating folate from food sources. In this case, if high acid folic intake continues to “hide”the symptoms of B12 deficiency for a long time, a slow but irreversible damage to the brain and nervous system may occur.

Acid Folic synthesis

Synthesis of Acid Folic from 1,1,3-Trichloroacetone and N-(p-Aminobenzoyl)glutamic acid and 2,4,5-Triamino-6-hydroxypyrimidine sulfate

Acid Folic Preparation Products And Raw materials

Raw materials

Orange red 1,1,3-Trichloroacetone Basic Orange 2 BUFFER SOLUTION(ACETIC ACID/SODIUM ACETATE) 3,5-DI-T-BUTYL-4-METHOXYBENZALDEHYDE

P-AMINOBENZAMIDE GLUTAMIC ACID 2,5,6-Triaminopyrimidin-4-ol sulphate Sodium metabisulfite Sodium bisulfite p-Aminobenzoyl Glutamic Acid

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Preparation Products

5,10-DiforMyl-5,6,7,8-tetrahydro Folic Acid Aminopterin Pterin-6-carboxylic acid DL-Pyroglutamic acid L-Tetrahydrofolic Acid

Acid Folic Suppliers

Global( 1272)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hengshui Haoye Chemical Co.,Ltd.	+86-2102300 +86-18632882519	hy@chemcoms.com	China	256	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	+86-576-88902229;+86-0576-88902229 +8613968687450	yuxin@yuxchem.com	China	122	58
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD	15202951039	jason@sgonekbio.com	China	268	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
Hebei Dongdu Import and Export Co. LTD	+86-15333296769 +86-15333296769	manager@cndongdu.com	China	71	58
shandong perfect biotechnology co.ltd	+86-53169958659; +8618596095638	sales@sdperfect.com	China	294	58
Across Biotech Jinan Co LTD	+8613031735486	frank@acrossbiotech.com	China	105	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Hebei Kangcang new material Technology Co., LTD	+8615713292910	Nancy@kangcang.com.cn	China	341	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	1094	58

Supplier	Advantage
Hengshui Haoye Chemical Co.,Ltd.	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	58
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Dongdu Import and Export Co. LTD	58
shandong perfect biotechnology co.ltd	58
Across Biotech Jinan Co LTD	58
Nantong Guangyuan Chemicl Co,Ltd	58
Hebei Kangcang new material Technology Co., LTD	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58

View Lastest Price from Acid Folic manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-10	Folic acid 59-30-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2021-02-05	Folic acid 59-30-3	US $1.00 / Kg/Bag	1g/Bag	99%	10 mt	Hebei Guanlang Biotechnology Co., Ltd.

Folic acid
59-30-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Folic acid
59-30-3
US $1.00 / Kg/Bag
99%
Hebei Guanlang Biotechnology Co., Ltd.

Folic acid Spectrum

Folic acid(59-30-3)MS Folic acid(59-30-3)¹HNMR Folic acid(59-30-3)¹³CNMR Folic acid(59-30-3)IR1 Folic acid(59-30-3)IR2

59-30-3(Acid Folic)Related Search:

Vitamin B12 Dihydromyrcenol DL-α-Tocopherol Riboflavin Benzoyl peroxide

Pyridoxine hydrochloride P-AMINOBENZAMIDE GLUTAMIC ACID Hyaluronic acid Sodium lauroylsarcosinate L-Glutamic acid

Vitamin D3 Vitamin A Citric acid Ascorbic Acid Menadione

Cocarboxylase Triamterene AMINOACETONITRILE HYDROGEN SULFATE Acid Folic

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KIT BLOOD DNA EZNA 5 TESTS PTEROYL-L-GLUTAMIC ACID PTEROYGLUTAMIC ACID nzoyl]- Pteroyl-L-monoglutamic acid pteroyl-l-monoglutamicacid USAF cb-13 usafcb-13 Vitamin Be vitaminbe NATURALFOLATEFROMFOOD FOLICACIDSUPPLEMENTS PTEROYLMONOGLUTAMATE Folsure 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino PteGlu Pteroyl-L-glutamic acid Vitamin M PGA Pteroylglutamic acid Folic Acid Hydrate FMOC-XANTHYL-L-CYSTEINE Folic acid >98% Acidum folicum, PteGlu, Pteroyl-L-glutamic acid, Vitamin M PteGlu, Pteroyl-L-glutamic acid, Vitamin M Vitamin M (Folic Acid) N-[4-[[(2-amino-1，4-dihydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]glutamic acid N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]-amino]benzoyl]gluamic acid Folic acid, 96-102%, pure N-[4-[[(2-Amino-1,4-dihydro-4-oxopteridin-6-yl)methyl]amino]benzoyl]-L-glutamic acid FOLIC ACID(VITAMIN M)(P) 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino PteGlu Folic acid Meets USP testing specifications Folic acid 0.2 L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]- (2S)-2-[[4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoyl]amino]glutaric acid dihydrate (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid dihydrate (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]pentanedioic acid dihydrate Folic acid Vetec(TM) reagent grade, >=97% (2S)-2-[[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]phenyl]-oxomethyl]amino]pentanedioic acid dihydrate (S)-2-(4-(((2-amino-4-hydroxypteridin-6-yl)methyl)amino)benzamido)pentanedioic acid dihydrate N-(4-{[(2-amino-4-hydroxypteridin-6-yl)methyl]amino}benzoyl)glutamic acid dihydrate Pteroyl N-[4-[[(2-AMINO-4-HYDROXY-6-PTERIDYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID n-4-[(2-amido-4-oxo-1,4-dihydro-6-terene)methylamino]benzoyl-l-glutamic acid VITAMIN M INCAFOLIC FOLSAN FOLIC ACID CYTOFOL l-pteroylglutamic acid 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-4-pteridino 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)- acfol(spain) Acifolic antianemiafactor component of Mission prenatal component of Plastulen-n factoru Folacid folaemin(netherlands) Folan folasic(australia) Folbal