Polysorbate 80
- CAS No.
- 9005-70-3
- Chemical Name:
- Polysorbate 80
- Synonyms
- 85;Tween 85;FEMA 2917;Tween®Terpienol;TWEEN 80KR;Emsorb 903;emsorb6903;BASF PS 80;POLYSORBATE
- CBNumber:
- CB00130920
- Molecular Formula:
- CH4
- Molecular Weight:
- 16.04246
- MDL Number:
- MFCD00082107
- MOL File:
- 9005-70-3.mol
| Melting point | -20 °C |
|---|---|
| Boiling point | 100 °C |
| Density | 1.028 g/mL at 20 °C |
| vapor pressure | <1 mm Hg ( 20 °C) |
| refractive index |
n |
| Flash point | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | Dispersible in water, in anhydrous ethanol, in ethyl acetate and in methanol, practically insoluble in fatty oils and in liquid paraffin. |
| form | viscous liquid |
| Specific Gravity | 1.030 (20/4℃) |
| color | Light yellow to Brown |
| Hydrophilic-Lipophilic Balance (HLB) | 11 |
| FDA 21 CFR | 172.840; 573.860; 172.836; 172.838; 172.842; 173.340; 175.105; 73.1001 |
| Indirect Additives used in Food Contact Substances | POLYSORBATE 85 |
| EWG's Food Scores | 1-6 |
| FDA UNII | A7F3N56197 |
| EPA Substance Registry System | Polysorbate 85 (9005-70-3) |
| Cosmetics Info | Polysorbate 80 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H412 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P273-P501 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | WG2934000 | |||||||||
| F | 3 | |||||||||
| HS Code | 34021300 | |||||||||
| Toxicity | LD50 orally in Rabbit: > 36000 mg/kg | |||||||||
| NFPA 704 |
|
Polysorbate 80 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P4634 | TWEEN? 85 | 9005-70-3 | 100ml | $55.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | P4634 | TWEEN® 85 | 9005-70-3 | 1gal | $161 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.22188 | Tween 85 for synthesis | 9005-70-3 | 500mL | $50.9 | 2024-03-01 | Buy |
| TCI Chemical | T0547 | Tween 85 (=Polyoxyethylene Sorbitan Trioleate) | 9005-70-3 | 25g | $19 | 2024-03-01 | Buy |
| TCI Chemical | T0547 | Tween 85 (=Polyoxyethylene Sorbitan Trioleate) | 9005-70-3 | 500g | $39 | 2024-03-01 | Buy |
Polysorbate 80 Chemical Properties,Uses,Production
Description
Polysorbate 80, a surfactant, has been widely used as a solvent for pharmacological experiments. Tween 80 can also reduce bacterial attachment and inhibit biofilm formation.
Definition
DrugBank: Polysorbate 80 is a hydrophilic nonionic surfactant. It is utilized as a surfactant in soaps and cosmetics and also as a lubricant in eye drops. In food or pharmaceutical products, it can act as an emulsifier. Polysorbate 80 is an excipient that is used to stabilize aqueous formulations of medications for parenteral administration or vaccinations. A solubilizing agent acts as a surfactant and increases the solubility of one agent in another. A substance that would not normally dissolve in a particular solution is able to dissolve with the use of a solubilizing agent. It is also known as an emulsifier, which helps ingredients mix together and prevent separation, and water-containing small amounts of salts, and is included in several vaccines licensed in the USA.
Biochem/physiol Actions
Polysorbate 80 has low-grade toxicity in both mice and rats when administered by the intraperitoneal and oral routes, producing mild to moderate depression of the central nervous system, significant reductions in locomotor activity and rectal temperatures, demonstration of ataxia and paralysing activity, and enhancement of pentobarbital sleep duration.
It had a dose-dependent antihypertensive effect in dogs administered intravenously.
Polysorbate 80 had no direct stimulatory or relaxant effect on the guinea-pig ileum or rat uterus, but it antagonised contractions induced by acetylcholine, histamine, barium, 5-hydroxytryptophan and carbachol in a dose-dependent manner.
A direct relaxant effect was observed on rabbit jejunum. Dose-dependent myocardial inhibition was observed on guinea pig and rabbit paired atrial preparations. In electrically driven guinea pig left atrial preparations, it exhibited a dose-dependent negative inotropic effect. It does not induce diuresis in rats below a dose of 2.5 ml/kg.
Polysorbate 80 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12468 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | daisy@crovellbio.com | China | 5957 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3002 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18219 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 940 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 2603 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 | admin@hblongbang.com | China | 902 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21688 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
View Lastest Price from Polysorbate 80 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Tween 80 Polysorbate 80
9005-65-6
|
US $90.00-45.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-03-11 | Tween 80 Polysorbate 80
9005-65-6
|
US $35.00-20.00 / kg | 500kg | 99.9 | 200tons | Shandong Juchuang Chemical Co., LTD | |
 |
2021-11-17 | Tween 80 Polysorbate 80
9005-65-6
|
US $0.00-0.00 / Kg/Drum | 25KG | 100% | 3000MT | Guangdong Huana Chemistry Co.,Ltd. |
-
- Tween 80 Polysorbate 80
9005-65-6
- US $90.00-45.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- Tween 80 Polysorbate 80
9005-65-6
- US $35.00-20.00 / kg
- 99.9
- Shandong Juchuang Chemical Co., LTD
-
- Tween 80 Polysorbate 80
9005-65-6
- US $0.00-0.00 / Kg/Drum
- 100%
- Guangdong Huana Chemistry Co.,Ltd.
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