Befunolol
- CAS No.
- 39552-01-7
- Chemical Name:
- Befunolol
- Synonyms
- Befunolol;Befunolol USP/EP/BP;(±)Befunolol,(±) Befunolol;2-acetyl-7-(2-hyroxy-3-isopropylaminopropoxy)benzofuran;2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran;(-)-2-Acetyl-7-[(S)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;(+)-2-Acetyl-7-[(R)-2-hydroxy-3-isopropylaminopropoxy]benzofuran;7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl ketone;ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofuranyl methyl;7-[2-Hydroxy-3-(iso-propylamino)propoxy]-2-benzofuranyl methyl ketone
- CBNumber:
- CB01116973
- Molecular Formula:
- C16H21NO4
- Molecular Weight:
- 291.34
- MDL Number:
- MFCD00864594
- MOL File:
- 39552-01-7.mol
| Melting point | 115° |
|---|---|
| Boiling point | 433.35°C (rough estimate) |
| Density | 1.1049 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated) |
| form | Solid |
| color | White to Off-White |
| CAS DataBase Reference | 39552-01-7 |
| EWG's Food Scores | 1 |
| FDA UNII | 418546MT3A |
| ATC code | S01ED06 |
Befunolol price More Price(2)
Befunolol Chemical Properties,Uses,Production
Originator
Bentos,Kakenyaku Kako,Japan,1983
Uses
β-Adrenergic blocker used as antiglaucoma agent in ophthalmie solutions
Uses
Befunolol is a β-adrenergic blocker with an intrinsic sympathomimetic action. But it can work as a β-adrenergic partial agonist in isolated organs.
Definition
ChEBI: Befunolol is a member of benzofurans.
Manufacturing Process
To 8.8 g of 2-acetyl-7-hydroxybenzofuran were added 80 ml of epichlorohydrin and 0.2 g of piperidine hydrochloride and the mixture was heated at 105°C for 3 hours. After the reaction, the excess of epichlorohydrin was evaporated and the resultant was distilled under reduced pressure to give 9.3 g of 2-acetyl-7-(2,3-epoxypropoxy)benzofuranhaving a boiling point of 175° to 176°C/0.7 mm Hg. 6 g of the product was dissolved in 30 ml of ethanol and to the solution was added 10 ml of isopropylamine. After refluxing the mixture for 40 minutes, the solvent was evaporated from the reaction mixture. The resulting residue was recrystallized from cyclohexane-acetone to give 6 g of 2-acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran having a melting point of 115°C.
Therapeutic Function
Beta-adrenergic blocker
Contact allergens
Befunolol was implicated in allergic contact dermatitis due to beta-blocker agents in eye-drops. Crosssensitivity has been described with levobunolol.
Befunolol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55934 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |