Alonimide
- CAS No.
- 2897-83-8
- Chemical Name:
- Alonimide
- Synonyms
- ALONIMID;Alonimide;spiro[piperidine-3,4'-tetralin]-1',2,6-trione;2H-spiro[naphthalene-1,3'-piperidine]-2',4,6'(3H)-trione;spiro[2,3-dihydronaphthalene-4,3'-piperidine]-1,2',6'-trione;2,3-Dihydrospiro[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione;Spiro[naphthalene-1(4H),3'-piperidine]-2',4,6'-trione, 2,3-dihydro-
- CBNumber:
- CB01177978
- Molecular Formula:
- C14H13NO3
- Molecular Weight:
- 243.26
- MDL Number:
- MOL File:
- 2897-83-8.mol
| Melting point | 201-203 °C |
|---|---|
| Boiling point | 510.9±50.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| pka | 11.55±0.20(Predicted) |
| FDA UNII | 14144823D4 |
Alonimide Chemical Properties,Uses,Production
Originator
Alonimide ,ZYF Pharm Chemical
Uses
Sedativehypnotic.
Manufacturing Process
To a stirred mixture of 58.6 g (0.5 M) of phenyl-acetonitrile and 150 g (1.5 M)
of ethyl acrylate was carefully added sodium methoxide in small increments
(about 0.1 g). The exothermic reaction was controlled by ice bath cooling to
keep the reaction mixture at 50°C. When further additions of sodium
methoxide were no longer exothermic, the reaction mixture was stirred for
one half hour more and the excess ethyl acrylate removed under reduced
pressure on a steam bath. The resulting oil was added to 1.500 g of
polyphosphoric acid and stirred on a steam bath for three hours. After cooling
to about 50°C, 0.5 liter of chloroform was added followed by additions of
crushed ice until the aqueous phase was free flowing. The chloroform layer
was separated and combined with three 150 ml chloroform extracts of the
aqueous layer. The organic phase was then dried over anhydrous magnesium
sulfate, filtered and concentrated to a semi-solid residue.
Recrystallization from acetone gave 2,3-dihydrospiro[naphthalene-1(4H),3'-
piperidine]-2',4,6'-trione, melting point 197°-199°C.
Therapeutic Function
Sedative, Hypnotic
Alonimide Preparation Products And Raw materials
Alonimide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 |
| Supplier | Advantage |
|---|---|
| Career Henan Chemica Co | 58 |
| Syntechem Co.,Ltd | 57 |