BROMOHEXINE
- CAS No.
- 3572-43-8
- Chemical Name:
- BROMOHEXINE
- Synonyms
- bromhexine;BroMhexine IMpurity E;Auxit;Na 274;Bromexine;Aids001646;Aids-001646;BROMOHEXINE;AKOS B015997;AURORA KA-7546
- CBNumber:
- CB0249452
- Molecular Formula:
- C14H20Br2N2
- Molecular Weight:
- 376.13
- MDL Number:
- MFCD00436295
- MOL File:
- 3572-43-8.mol
- MSDS File:
- SDS
| Melting point | 238℃ |
|---|---|
| Boiling point | 413.8±40.0 °C(Predicted) |
| Density | 1.57 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: 75 mg/mL (199.40 mM);Ethanol: 75 mg/mL (199.40 mM) |
| pka | 8.34±0.20(Predicted) |
| Water Solubility | Water: Insoluble |
| FDA UNII | Q1J152VB1P |
| ATC code | R05CB02 |
SAFETY
Risk and Safety Statements
| Signal word | Warning |
|---|---|
| Hazard statements | H410-H400 |
| Precautionary statements | P273-P391-P501-P273-P391-P501 |
| Toxicity | Approx LD50 orally in rabbits: >10 g/kg (Boyd, Sheppard) |
BROMOHEXINE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0007117 | N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE 95.00% | 3572-43-8 | 1G | $477.38 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0027098 | BROMHEXINE IMPURITY E 95.00% | 3572-43-8 | 5MG | $502.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007117 | N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE 95.00% | 3572-43-8 | 25G | $1422.46 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007117 | N-(2-AMINO-3,5-DIBROMOBENZYL)-N-CYCLOHEXYL-N-METHYLAMINE 95.00% | 3572-43-8 | 50G | $2392.25 | 2021-12-16 | Buy |
| Chemenu | CM201336 | 2,4-dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline 95% | 3572-43-8 | 1g | $580 | 2021-12-16 | Buy |
BROMOHEXINE Chemical Properties,Uses,Production
Originator
Bisolvon,Boehringer Ingelheim,Switz.,1963
Uses
Expectorant; mucolytic.
Definition
ChEBI: A substituted aniline that is 2,4-dibromoaniline which is substituted at position 6 by a [cyclohexyl(methyl)amino]methyl group. It is used (as the monohydrochloride salt) as a mucolytic for the treatment of respiratory disorders associated with productive ough (i.e. a cough characterised by the production of sputum).
Manufacturing Process
In initial steps, 2-nitrobenzylbromide and cyclohexylmethylamine are reacted
and that initial product reacted with hydrazine to give N-(2-aminobenzyl)-Nmethyl-
cyclohexylamine.
A solution of 29.3 g of bromine in 50 cc of glacial acetic acid was slowly added
dropwise to a solution of 159 g of N-(2-aminobenzyl)-N-methylcyclohexylamine,
accompanied by stirring. The glacial acetic acid was
decanted from the precipitate formed during the addition of the bromine
solution, and the precipitate was thereafter shaken with 200 cc of 2N sodium
hydroxide and 600cc of chloroform until all of the solids went into solution.
The chloroform phase was allowed to separate from the aqueous phase. The
chloroform phase was decanted, evaporated to dryness and the residue was
dissolved in absolute ether. The resulting solution was found to be a solution
of N-(2-amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine in ethanol. Upon
introducing hydrogen chloride into this solution, the hydrochloride of N-(2-
amino-3,5-dibromobenzyl)-N-methyl-cyclohexylamine precipitated out. It had
a melting point of 232°-235°C (decomposition).
Therapeutic Function
Expectorant; Mucolytic
BROMOHEXINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| airuikechemical co., ltd. | +undefined86-15315557071 | sales05@airuikechemical.com | China | 994 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 | sarah@tnjone.com | China | 1141 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | 1012@dideu.com | China | 2664 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from BROMOHEXINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-29 | Bromhexine
3572-43-8
|
US $0.00 / kg | 1kg | 99% | 10000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | |
 |
2024-04-10 | Bromhexine
3572-43-8
|
US $0.00-0.00 / mg | 10mg | 90%+ | 10g | Guangzhou PI PI BIOTECH INC | |
 |
2024-04-03 | bromhexine
3572-43-8
|
US $0.00-0.00 / g | 1g | 99.99% | 20 tons | airuikechemical co., ltd. |
-
- Bromhexine
3572-43-8
- US $0.00 / kg
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
-
- Bromhexine
3572-43-8
- US $0.00-0.00 / mg
- 90%+
- Guangzhou PI PI BIOTECH INC
-
- bromhexine
3572-43-8
- US $0.00-0.00 / g
- 99.99%
- airuikechemical co., ltd.