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TMS

TMS structure

CAS No.: 24144-92-1

Chemical Name:: TMS

Synonyms: CS-961;SMB 00388;TMS, >=98%;5'-tetramethoxystilbene;3,5,2’,4’-Tetramethoxystilbene;2,3',4,5'-TETRAMETHOXYSTILBENE;(E)-2,3',4,5'-TETRAMETHOXYSTILBENE;TMS - Trans-2,3',4,5'-tetramethoxystilbene;(E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene;1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE

CBNumber:: CB0347220

Molecular Formula:: C18H20O4

Molecular Weight:: 300.35

MDL Number:: MFCD03428621

MOL File:: 24144-92-1.mol

MSDS File:: SDS

Last updated:2023-06-08 09:01:58

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TMS Properties

Melting point	78-79 °C
Boiling point	459.9±40.0 °C(Predicted)
Density	1.117±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
form	Powder

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P280-P305+P351+P338

NFPA 704

	0
2		0

TMS price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10038	TMS ≥98%	24144-92-1	1mg	$16	2024-03-01	Buy
Cayman Chemical	10038	TMS ≥98%	24144-92-1	5mg	$63	2024-03-01	Buy
Cayman Chemical	10038	TMS ≥98%	24144-92-1	10mg	$109	2024-03-01	Buy
Cayman Chemical	10038	TMS ≥98%	24144-92-1	50mg	$469	2024-03-01	Buy
TRC	T298900	2,4,3'',5''-Tetramethoxystilbene	24144-92-1	1g	$1695	2021-12-16	Buy

Product number	Packaging	Price	Buy
10038	1mg	$16	Buy
10038	5mg	$63	Buy
10038	10mg	$109	Buy
10038	50mg	$469	Buy
T298900	1g	$1695	Buy

TMS Chemical Properties,Uses,Production

Uses

2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Uses

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.

Uses

2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Definition

ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .

TMS Preparation Products And Raw materials

Raw materials

Preparation Products

TMS Suppliers

Global( 83)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from TMS manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-02	2,4,3',5'-tetramethoxystilbene 24144-92-1	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

2,4,3',5'-tetramethoxystilbene
24144-92-1
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

24144-92-1(TMS)Related Search:

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1-TMS-1H-BENZOTRIAZOLE POLY(DIMETHYLSILOXANE-CO-METHYLHYDRO-SIL OXANE), TMS TERM, VISC CA. 260 CST Acetonitrile-d3 Benzene-D6 Tetrakis(trimethylsilyl)silane ((TMS)4Si )

Pyridine-d5, contains 1 v/v% TMS, 99 atom % D, for NMR,Pyridine-d5, with 0.03% TMS, 100.0 atom% D, for NMR Chloroform-d ACETONE-D6 TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY] N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS)

1-(TMS)ETHYNYLCYCLOHEXENE 1-TMS-1H-BENZOTRIAZOLE Cytochrome P450 1B1 Inhibitor, TMS

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(E)-2,3',4,5'-TETRAMETHOXYSTILBENE 2,3',4,5'-TETRAMETHOXYSTILBENE 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE 3,5,2’,4’-Tetramethoxystilbene Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy- (E)-1-(3,5-Dimethoxystyryl)-2,4-dimethoxybenzene TMS, >=98% TMS - Trans-2,3',4,5'-tetramethoxystilbene CS-961 5'-tetramethoxystilbene SMB 00388 24144-92-1 Antitumour