MOFEBUTAZONE
- CAS No.
- 2210-63-1
- Chemical Name:
- MOFEBUTAZONE
- Synonyms
- 2fdbp;monazan;mobuzon;reumatox;monobutyl;mobutazon;MOFEBUTAZONE;monorheumetten;arcomonoltablets;monophenylbutazone
- CBNumber:
- CB0667894
- Molecular Formula:
- C13H16N2O2
- Molecular Weight:
- 232.28
- MDL Number:
- MFCD00022559
- MOL File:
- 2210-63-1.mol
| Melting point | 102-103° |
|---|---|
| Boiling point | 374.44°C (rough estimate) |
| Density | 1.1099 (rough estimate) |
| refractive index | 1.6450 (estimate) |
| storage temp. | Room Temperature |
| solubility | DMSO (Slightly), Methanol (Sparingly) |
| form | Solid |
| pka | 5.22±0.10(Predicted) |
| color | White to Off-White |
| FDA UNII | SPW36WUI5Z |
| ATC code | M01AA02,M02AA02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H332-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Toxicity | LD50 i.v. in mice: 600 mg/kg (Schoetensack) |
MOFEBUTAZONE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M485400 | Mofebutazone | 2210-63-1 | 1g | $150 | 2021-12-16 | Buy |
| TRC | M485400 | Mofebutazone | 2210-63-1 | 500mg | $100 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010057 | MOFEBUTAZONE 95.00% | 2210-63-1 | 500MG | $721.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010057 | MOFEBUTAZONE 95.00% | 2210-63-1 | 1G | $1080.45 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 52412 | Mofebutazone | 2210-63-1 | 10g | $1250 | 2021-12-16 | Buy |
MOFEBUTAZONE Chemical Properties,Uses,Production
Originator
Butaphen,Wiedenmann
Uses
Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.
Definition
ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.
Manufacturing Process
A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.
brand name
Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.
Therapeutic Function
Antirheumatic, Analgesic, Antiinflammatory
World Health Organization (WHO)
Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Clinical Use
Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).
MOFEBUTAZONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 18521735133 18521732826; | market@aladdin-e.com | China | 25014 | 65 |